Chloramphenicol and Neomycin, Eye

Anti-infective, Eye · Aminoglycoside/Chloramphenicol

Indications

Bacterial conjunctivitis.

Dosage

Drop: Adults & Children: 1-2 drops 4-6 times for 72 hr. May or more frequently if required. May increase interval after 48 hr. Administration should be continued 48 hr after symptoms have disappeared.

Adverse Effects

Local sensitivity reactions. Aplastic anaemia (rare).

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Precautions: Contact lenses.

Advice to Patient

Avoid prolonged use.

Pharmacokinetics

CHLORAMPHENICOL: Absorption: Well absorbed. Metabolism: Hepatic. Half-life elimination: Adults (normal hepatic and renal function): 1.5-3.5 hrs. Impaired renal function: 3-4 hrs. Severely impaired hepatic function: 4.6-11.6 hrs. Children (1 mth-16 yrs): 3-6.5 hrs. Infants 1-2 days old: 24 hrs or longer and is highly variable, esp in low birth-wt infants. NEOMYCIN: Half-life elimination: 2-3 hrs. Excretion: Urine (absorbed portion of drug). Faeces (unabsorbed portion of drug).

Brands with this active ingredient

• Antibioptal

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.