Ceftizoxime
Cephalosporin · Cephalosporin
Indications
Infections of the lower respiratory tract, skin and soft tissues. Septicaemia. Severe infections in immunocompromised patients. UTI and gonorrhoea.
Dosage
Adults: IM/IV: 1-2 gm every 8-12 hr, up to 2 gm every 4 hr or 4 gm every 8 hr for life-threatening infection. Children: > 6 mth: 150-200 mg/kg/day divided every 6-8 hr; max 12 gm/day. Bone Infection: IM/IV: Adults: 1-2 gm every 8-12 hr. Max: 6 gm/day. Children: > 6 mth: 50 mg/kg every 6-8 hr, not to exceed adult dose. Meningitis/ Septicaemia: IV: Adults: 3-4 gm every 8 hr. Children: > 6 mth: 50 mg/kg every 6-8 hr, not to exceed adult dose.
Administration
IM: Inject deep IM into large muscle mass. IV: Inject direct IV over 3-5 min. Infuse intermittent infusion over 30 min. Reconstitution: IV: Reconstitute with SWFI as follows: For 500 mg vial: Add 5 mL, 1 gm vial: Add 10 mL, 2 gm vial: Add 20 mL. Shake well. Dilute reconstituted solution further with 50-100 mL of a compatible solution, such as NS or D5W before administration. IM: Reconstitute with SWFI as follows: For 500 mg vial: Add 1.5 mL, 1 gm vial: Add 3 mL. 2 gm vial: Add 6 mL. Shake well. Divide 2 gm doses and administer in different sites. Compatibility: Stable in D5¼NS, D5½NS, D5NS, D5W, D10W, LR, NS, sodium bicarbonate 5%.
Adverse Effects
Pain at inj site, hypersensitivity reactions. Gl disturbances, eosinophilia, neutropenia, leucopenia, thrombocytopenia, rise in liver enzymes and blood urea. Positive Coomb's test.
Risk Factor (Pregnancy/Lactation)
Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Precautions: Renal impairment. Hypersensitivity to penicillins.
Interactions
Loop diuretics, aminoglycosides.
Advice to Patient
This medication is to be administered by injection or infusion only. Contact prescriber if there is burning/swelling/redness/pain at injection or infusion site or if there is rash, hives, itching, difficulty in breathing or swallowing, severe unrelieved diarrhoea, vaginal drainage or itching, mouth sores, blood/pus/mucus in stool or urine, easy bruising or bleeding, unusual chills or fever. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.
Pharmacokinetics
Metabolism: Not metabolized. Half-life elimination: 1.7 hrs. Prolonged in neonates and in patients with renal impairment. Time to peak, plasma: 1 hr. Excretion: Urine.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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