Carbimazole

Thyroid Therapy · Antithyroid

Indications

Thyrotoxicosis.

Dosage

Adults: Initially, 20-60 mg daily in two or three divided doses until patient is euthyroid. Maintenance, 5-15 mg daily for 6-18 mth. Alternatively, continue with 20-60 mg daily and supplemental thyroxine 50-150 mcg daily for 6-18 mth. Children: Initially, 5-15 mg daily in divided doses.

Adverse Effects

Rashes, nausea, headache, GI upset, hepatic disorders, skin reactions, arthralgia. Bone marrow depression.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Tracheal obstruction. Severe blood disorders. Severe hepatic impairment. Precautions: Warn patients to inform doctor if sore throat, mouth ulcers, bruising, fever, malaise or non-specific illness develops. Mild to moderate hepatic impairment, intrathoracic goitre. Elderly.

Interactions

Anticoagulants, digoxin, theophylline, radio-iodine, myelosuppressants.

Advice to Patient

Take before or after meals. Swallow with a full glass of water. Take at the same time each day. If you miss a dose, take it as soon as you remember. If it is time for the next dose, then take both doses together. Inform prescriber about sore throats and mouth ulcers.

Pharmacokinetics

Absorption: Rapidly absorbed from the GI tract. Metabolism: Hepatic. Rapidly and completely metabolized to thiamazole in the body. Half-life elimination: Thiamazole: 3-6 hrs. Increased in hepatic and renal impairment. Time to peak, plasma: Oral: 1-2 hrs. Excretion: Urine (90%). Faeces (remainder).

Brands with this active ingredient

• Carbil
• Neo-Mercazole
• Thyrazol

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.