Basiliximab

Immunomodulator · Immunosuppressant

Indications

Prophylaxis of renal allograft rejection. As an adjunct to Neoral and corticosteroids for the prophylaxis of acute organ rejection in de novo allogeneic renal transplantation.

Dosage

See literature. Two doses, the first within 2 hr before transplantation surgery, the sec 4 days after transplantation. Adults: 20 mg basiliximab per dose. Children: (aged 2 yr or older) weighing less than 40 kg: 10 mg per dose. Children (aged 2 yr or older) weighing 40 kg or more, same as adult dose.

Administration

For central or peripheral IV administration only. Reconstituted solution should be given either as a bolus injection or diluted and administered as an IV infusion over 20-30 min. Reconstitution: To prepare the reconstituted solution, add 2.5 mL (10 mg vial) or 5 mL (20 mg vial) of SWFI, using aseptic technique, to the vial containing the basiliximab powder. Shake the vial gently to dissolve the powder. The reconstituted solution is isotonic and may be given either as a bolus injection or diluted to a volume of 25 mL (10 mg vial) or 50 mL (20 mg vial) with NS or D5W for infusion. When mixing the solution, gently invert the bag in order to avoid foaming, do not shake. Stability: Store lyophilized basiliximab under refrigerated conditions 2°C-8°C (36°F-46°F). It is recommended that after reconstitution, the solution should be used immediately. If not used immediately, it can be stored…

Adverse Effects

Rare case of hypersensitivity/anaphylactoid type reaction such as rash, urticaria, sneezing, wheezing, bronchospasm, pulmonary oedema, cardiac failure, respiratory failure and capillary leak syndrome have been reported.

Risk Factor (Pregnancy/Lactation)

Contraindications: Pregnancy. Women receiving Simulect should not breast-feed for 8 weeks after the second dose.

Pharmacokinetics

Duration of action: 36 days. Half-life elimination: Terminal: 7.2 ± 3.2 days. Time to peak, plasma: 30 mins.

Brands with this active ingredient

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.