Azilsartan Medoxomil

Angiotensin-II Antagonist · Angiotensin II antagonist

Indications

Treatment of hypertension.

Dosage

Adults: 80 mg once daily. 40 mg once daily in patients with volume depletion. Children: Not recommended.

Adverse Effects

Orthostatic hypotension, dizziness, fatigue, diarrhoea, nausea, decreased hemoglobin, decreased hematocrit, decreased RBC, muscle spasm, weakness, increased serum creatinine, cough.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Concomitant use with aliskiren in patients with diabetes mellitus.

Interactions

Amifostine, cyclosporine, lithium, NSAIDs, anti-inflammatory agents, K-sparing diuretics, rituximab, sodium phosphate, alfuzosin, aliskiren, diazoxide, eplerenone, MAO inhibitors, pentoxifylline, phosphodiesterase 5 inhibitors, potassium salts, prostacyclin analogues, tolvaptan, trimethoprim, methylphenidate, rifamycin derivatives.

Advice to Patient

Take with or without meals.

Pharmacokinetics

Bioavailability: 60%. Metabolism: Hepatic. Half-life elimination: 11 hrs. Time to peak, plasma: 1.5-3 hrs. Excretion: Faeces (55%). Urine (42%).

Brands with this active ingredient

• Avincer
• Avincer-CD
• Azilaan-C
• Azilazon
• Zelwist
• Zelwist-C

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.