Antithymocytes Immunoglobulin

Immunomodulator · Immunosuppressant

Indications

Prophylaxis of organ rejection in renal and heart allograft recipients and for the treatment of corticoids-resistant allograft rejection in renal transplantation. Tolerability is increased by pretreatment with an intravenous corticosteroid and antihistamine; an antipyretic drug such as paracetamol may also be beneficial.

Dosage

Heart transplantation: By I/V Inf: Over at least 6 hr,1 - 2.5 mg/kg daily for 3 - 5 days. Renal transplantation: By I/V Inf: Over at least 6 hr, 1 - 1.5 mg/kg daily for 3- 9 days. Corticosteroid resistance renal graft rejection: By I/V Inf: Over at least 6 hr, 1.5 mg/kg daily for 7 - 14 days.

Administration

The recommended route of administration is IV infusion using a high-flow vein. Anti-thymocyte globulin should be infused over a minimum of 6 hours for the first infusion and over at least 4 hours on subsequent days of therapy. Anti-thymocyte globulin should be administered through an in-line 0.22 mcm filter. Stability: Store in refrigerator between 2°C-8°C (36°F-46°F). Protect from light. Do not freeze. Reconstituted vials of anti-thymocyte globulin should be used within 4 hours. Infusion solutions of anti-thymocyte globulin must be used immediately. Any unused drug remaining after infusion must be discarded.

Adverse Effects

Nausea, vomiting, dysphagia, diarrhoea, hypotension, infusion related reaction, serum sickness, fever, shivering, increased susceptibility to infection, increased susceptibility to malignancy, lymphopaenia, neutropenia, thrombocytopenia, myalgia, pruritus, rash.

Interactions

Live vaccines.

Pharmacokinetics

Half-life elimination: 30 days.

Brands with this active ingredient

• ATG-F
• Grafalon
• Thymogam
• Thymoglobuline

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.