Altis

by Ray

Active ingredients: Artemether, Artemether and Lumefantrine

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About Artemether

Antimalarial

Uses

Severe malaria including cerebral malaria and as a second line treatment in chloroquine resistant falciparum malaria.

How to take it

Adults: IM or IV infusion: First dose 120 mg; followed by 60 mg after 4-6 hr; then 60 mg after every 24 hr once daily. The total duration of treatment is 5 consecutive days. Total doses are 360-480 mg for adults. Children: IM or IV infusion: Age 7 yr or more, same as adult dose. Below 7 yr age: 1.5 mg/kg. Both the age group children should be given the sec dose after 4-6 hr; then one dose after every 24 hr once daily. The total duration of treatment is 5 consecutive days. Deep IM injection or slow IV infusion. IM injection: Dissolve 60 mg of Artemether with 1 mL of 5% sodium bicarbonate solution for injection before use. IV infusion: Dissolve 60 mg of Artemether with 1 mL of 5% sodium…

Side effects

Transient and reversible reticulocytopenia, drug fever, drug rash, bradycardia, transient first degree heart block and transient & reversible elevation of serum transaminases. Nausea, abdominal pain, diarrhoea, headache.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Electrolyte disturbances, concomitant use with other drugs known to cause QT-interval prolongation. Precautions: History of arrhythmias, of clinical relevant bradycardia and of congestive heart failure accompanied by reduced ventricular ejection fraction; family history of sudden death or of congenital QT interval prolongation.

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Interactions with Artemether

Antioxidant drugs e.g. vitamin E, C. Additive effect seen with chloroquine. Antagonistic effect seen with pyrimethamine and sulphonamides.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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