Dronopam

by Zafa

Active ingredient: Pamidronate disodium

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About Pamidronate Disodium

Drugs affecting Bone Metabolism

Uses

Inj: Treatment of tumour induced hypercalcaemia, osteolytic lesions and bone pain due to bone metastases associated with breast cancer or multiple myeloma. Paget's disease.

How to take it

Adults: INJECTION: By slow IV infusion; max rate 60 mg/hr. Tumour induced hypercalcaemia: Total dosage to be determined by patients initial plasma calcium levels. Infuse slowly; max rate 30 mg in 2 hr. Max dose 90 mg per treatment for both initial and repeat courses. See literature. Osteolytic lesions, bone pain: 90 mg every 4 wk. In breast cancer this dose may be given every 3 wk to coincide with chemotherapy. Paget's disease: 30 mg once wkly for 6 consecutive wk; total dose 180 mg. Alternatively, 30 mg in wk 1, then 60 mg in wk 2, wk 4 and wk 6; total dose 210 mg. Increase if necessary to a max total dose 360 mg. Regimen can be repeated every 6 mth until remission and if relapse occurs.…

Side effects

Mild transient pyrexia. Transient lymphocytopenia. Asymptomatic hypocalcaemia. Hypomagnesaemia, infusion site reactions, transient bone pain, arthralgia, myalgia, headache. GI upset, lymphocytopenia. Rarely, leucopenia, anaemia, other biochemical disturbances, fever, flu-like symptoms, rash, insomnia, somnolence, hypertension, conjunctivitis, anorexia, hypophosphataemia, hypokalaemia, raised serum creatinine, atrial fibrillation.

Pregnancy and breastfeeding

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Caution advised or effect undetermined. Precautions: Renal impairment, cardiac disease, previous thyroid surgery. Possibility of precipitating convulsions. Monitor serum electrolytes, calcium and phosphate. During prolonged use, monitor renal function.

Advice

For bone pain, consult prescriber for analgesic. Contact prescriber if there is unusual muscle spasm/pain/twitching, fever, fatigue, acute bone pain, severe diarrhoea or constipation. During infusion and for 2-3 hours after completion, avoid meals high in calcium or vitamins with minerals. Regular mouth care is required during therapy. If you have to undergo a dental surgery, inform prescriber about it.

Full information on Pamidronate Disodium →

Interactions with Pamidronate Disodium

Infusions of solutions containing calcium, hypocalcaemic therapy, other diphosphonates, plicamycin, nephrotoxic drugs.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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