Donep

by Genetics

Active ingredient: Donepezil HCl

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In stock at Healify — same active ingredient

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About Donepezil

Other CNS Drugs

Uses

Mild to moderately severe Alzheimer's dementia.

How to take it

Adults: Initially 5 mg once daily at bedtime. Increase if necessary to max 10 mg at bedtime after 1 mth. Assess response 2-4 mth after reaching maintenance dose and only continue if positive evidence of benefit. Children: Not recommended.

Side effects

GI upset, fatigue, pain, common cold, muscle cramps, headache, insomnia, dizziness, syncope, coryza, anorexia, rash, pruritus, urinary incontinence, psychiatric disturbances. Rarely, bradycardia, SA or AV block, seizures, raised creatine kinase, extra-pyramidal symptoms, GI haemorrhage, GI or duodenal ulcers. Liver dysfunction (consider withdrawal). Neuroleptic malignant syndrome.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Precautions: Diagnosis and treatment must be under supervision of a clinician experienced in Alzheimer's dementia. Hepatic impairment, supraventricular conduction disturbances, history or risk of GI ulceration, asthma, COPD, bladder outflow obstruction, seizures, extra-pyramidal symptoms. Risk of neuroleptic malignant syndrome.

Advice

Take with or without meals. Take medication immediately before going to bed. Contact prescriber if there is dizziness, stomach discomfort, increased saliva/tears/urination/sweating, flushing of skin, chest pain or palpitations, increased fatigue, lack of sleep, acute headache, unrelieved diarrhoea, depression, increased muscle, body or joint pain, change in vision, blurred vision, difficulty in breathing, black or dark coloured stool. Do not take NSAIDs during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Change position slowly from sitting or lying to standing.

Full information on Donepezil →

Interactions with Donepezil

Neuromuscular blockers, cholinergics and anticholinergic agents, anaesthetics, beta-blockers, P450 enzyme inducers or inhibitors, antipsychotics, inducers and inhibitors of CYP3A4 or CYP2D6.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.