Dexadron

by Epoch

Active ingredient: Dexamethasone

Packs

About Dexamethasone, Inj/Oral

Corticosteroid, Systemic

Uses

Cortisone therapy in: Immuno-allergology, rheumatology, endocrinology, dermatology, ophthalmology, gastro-enterology, cardiology, pulmonary disease, haematology. COVID-19: In patients who have tested to be COVID-19 positive and require oxygen support.

How to take it

Note: Dexamethasone 1 mg equiv to dexamethasone phosphate 1.2 mg equiv to dexamethasone sodium phosphate l.3 mg. Adults: Antiemetic: Prophylaxis: Oral/IV: 10-20 mg 15-30 min before treatment on each treatment day. Continuous infusion regimen: IV: 10 mg every 12 hrs on each treatment day. Mildly emetogenic therapy: Oral/IM/IV: 4 mg every 4-6 hrs. Delayed nausea vomiting: Oral: 4-10 mg 1-2 times/day for 2-4 days or 8 mg every 12 hrs for 2 days; then 4 mg every 12 hrs for 2 days or 20 mg 1 hr before chemotherapy; then 10 mg 12 hrs after chemotherapy; then 8 mg every 12 hrs for 4 doses; then 4 mg every 12 hrs for 4 doses. Anti-inflammatory: Oral/IM/IV (inj as sodium phosphate): 0.75-9 mg/day in…

Side effects

Endocrine irregularities including menstrual problems, Cushingoid state, adrenal suppression, growth suppression in children. Increased susceptibility to infection, increased severity of infection. Fluid/electrolyte disturbance, hypertension, negative protein, nitrogen and calcium balance. Myopathy, tendon rupture, osteoporosis, osteonecrosis and fractures. Impaired wound healing, sweating, hirsutism, striae, telangiectasia, acne. GI disturbance, peptic ulceration, acute pancreatitis, candidiasis. Psychiatric effects, neurological effects, insomnia. Diabetes, impaired glucose tolerance, weight gain, increased appetite. Ocular disturbances including cataracts, raised intraocular pressure,…

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Systemic fungal infections unless specific anti-infective therapy is used. Head injury, stroke. Precautions: Active infections not controlled by antibiotics. Latent or active amoebiasis. History of TB, septicaemia, symptoms may be masked. Avoid or maintain extreme cautions in chickenpox, measles, psychiatric disorders, renal impairment, hepatic failure, cirrhosis, active peptic ulcer, Myasthaenia gravis, previous steroid myopathy, osteoporosis, epilepsy, hypothyroidism, diabetes, adrenal suppression, hypertension, recent MI, congestive heart failure, thromboembolic disorders, glaucoma,…

Advice

Take with meals. Do not stop taking drug abruptly, gradually lower down the dose then stop. Contact prescriber if there is increased nervousness, sleep disturbances, sore throat, unrecovered injuries, easy bruising, loss of skin colour, excessive growth of body hair, changes in vision, sudden or rapid weight gain (>3 lb per week), swelling of face/ankles/hands/feet, difficulty in breathing, muscle weakness, dark stools or change in color of stool, amenorrhoea, constant abdominal pain or if there is no improvement or worsening of condition. Consult prescriber if you feel more stressed out than normal because dosage may need to be adjusted. Avoid alcohol, limit intake of caffeine and…

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Interactions with Dexamethasone, Inj/Oral

Live vaccines or other vaccines, anticoagulants, hypoglycaemia agents, antihypertensives, diuretics, erythromycin, rifamycin, amphotericin, azole antifungals, ritonavir, cyclosporin, cardiac glycosides. Oestrogens including oral contraceptives, somatropin. Carbamazepine, phenytoin, primidone, barbiturates. Muscle relaxants, NSAIDs, salicylates, sympathomimetics, mifepristone, methotrexate, theophylline, aprepitant.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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