Deltacortril

by Pfizer

Active ingredient: Prednisolone

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About Prednisolone, Inj/Oral

Corticosteroid, Systemic

Uses

Collagen and allergic conditions requiring systemic corticosteroid therapy.

How to take it

Adults: ORAL: Usual range: 5-60 mg daily. Elderly: Use lowest effective dose. Multiple sclerosis: 200 mg/day for 1 wk followed by 80 mg every other day for 1 mth. Rheumatoid arthritis: Initial: 5-7.5 mg daily; adjust dose as necessary. Children: ORAL: Autoimmune inflammatory disorders (including juvenile idiopathic arthritis, connective tissue disorders and systemic lupus erythematosus): 1 mth-18 yr, initially 1-2 mg/kg once daily (usual max 60 mg daily), then reduced after a few days if appropriate. Autoimmune hepatitis: 1 mth-18 yr, initially 2 mg/kg once daily (max 40 mg daily) then reduced to minimum effective dose. Corticosteroid replacement therapy: 12-18 yr, 2-2.5 mg/square meter…

Side effects

Endocrine irregularities including menstrual problems, Cushingoid state, adrenal suppression, growth suppression in children. Increased susceptibility to infection, increased severity of infection. Fluid/electrolyte disturbance, hypertension, negative protein, nitrogen and calcium balance. Myopathy, tendon rupture, osteoporosis, osteonecrosis and fractures. Impaired wound healing, sweating, hirsutism, striae, telangiectasia, acne. GI disturbance, peptic ulceration, acute pancreatitis, candidiasis. Psychiatric effects, neurological effects, insomnia. Diabetes, impaired glucose tolerance, weight gain, increased appetite. Ocular disturbances including cataracts, raised intraocular pressure,…

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Systemic fungal infections unless specific anti-infective therapy is used. Head injury, stroke. Precautions: Active infections not controlled by antibiotics. Latent or active amoebiasis. History of TB, septicaemia, symptoms may be masked. Avoid or maintain extreme cautions in chickenpox, measles, psychiatric disorders, renal impairment, hepatic failure, cirrhosis, active peptic ulcer, Myasthaenia gravis, previous steroid myopathy, osteoporosis, epilepsy, hypothyroidism, diabetes, adrenal suppression, hypertension, recent MI, congestive heart failure, thromboembolic disorders, glaucoma,…

Advice

Take with meals. Place orally disintegrating tablet on tongue, do not split, cut or break it. Do not stop taking medication abruptly, gradually lower down the dose then stop. Contact prescriber if there is worsening of condition, increased nervousness, unhealed injuries, sore throat, sleep disturbances, excessive body hair growth, changes in vision, loss of skin colour, rapid or sudden weight gain (>3 lb per week), swelling of face/hands/ankles/feet, black or dark coloured stools, difficulty in breathing, muscle weakness, joint pain, mood changes, constant abdominal pain or if there is no improvement in condition. Consult prescriber if you feel more stressed out than normal because dosage…

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Interactions with Prednisolone, Inj/Oral

Live vaccines or other vaccines, anticoagulants, hypoglycaemia agents, antihypertensives, diuretics, erythromycin, rifamycin, amphotericin, azole antifungals, ritonavir, cyclosporin, cardiac glycosides. Oestrogens including oral contraceptives, somatropin. Carbamazepine, phenytoin, primidone, barbiturates. Muscle relaxants, NSAIDs, salicylates, sympathomimetics, mifepristone, methotrexate, theophylline, aprepitant.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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