DAC

by Medinet

Active ingredient: Dacarbazine

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About Dacarbazine

Cytostatic

Uses

Malignancy especially malignant melanoma and malignant lymphomas. Testicular tumours, colorectal cancers, tumours of GIT, CNS, soft tissues.

How to take it

Adults: 200-500 mg/m². Refer individual protocol. Children: Not recommended. IV: Irritant: Infuse over 30-60 min; rapid infusion may cause severe venous irritation. Reconstitution: Reconstitute with a minimum of 2 mL (100 mg vial) or 4 mL (200 mg vial) of SWFI, D5W, or NS. Dilute to a concentration of 10 mg/mL. Standard IV dilution: 250-500 mL D5W or NS. Compatibility: Stable in NS, SWFI. Stability: Reconstituted solution is stable for 24 hours at room temperature (20°C) and 96 hours under refrigeration (4°C). Solutions for infusion (in D5W or NS) are stable for 24 hours at room temperature and protected from light. Decomposed drug turns pink.

Side effects

Alopecia, nausea, vomiting, anorexia, myelosuppression, leucopenia, thrombocytopenia, increased liver enzymes, anaemia, diarrhoea, taste disturbance, rash, photosensitivity, renal function test abnormalities.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined.

Advice

This medication is administered by infusion. Before infusion, limit oral intake for 4-6 hours. Inform prescriber immediately if there is redness/swelling/burning/pain at infusion site. Contact prescriber if there is severe nausea, vomiting, diarrhoea, loss of appetite, headache, sinus congestion, fever, muscle pain, change in gait, numbness in extremities, rash, easy bruising or bleeding, difficulty in breathing, dark coloured stool, change in colour of urine, yellowing of skin or eyes. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Take small, frequent meals to maintain good nutritional status. Avoid highly crowded places…

Full information on Dacarbazine →

Interactions with Dacarbazine

BCG, clozapine, natalizumab, pimecrolimus, tacrolimus (topical), live vaccines (avoid), abiraterone acetate, CYP1A2 inhibitors, CYP2E1 inhibitors, deferasirox, denosumab, MAO inhibitors, roflumilast, trastuzumab.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.