Cyramza

by Eli Lilly

Active ingredient: Ramucirumab

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About Ramucirumab

Cytostatic

Uses

In combination with docetaxel for metastatic non-small cell lung cancer (NSCLC) with disease progression on or after platinum-based chemotherapy. As a single agent or in combination with paclitaxel, for treatment of advanced gastric or gastro-esophageal junction adenocarcinoma, with disease progression on or after prior fluoropyrimidine-or platinum-containing chemotherapy. In combination with FOLFIRI for the treatment of patients with metastatic colorectal cancer (mCRC) whose disease has progressed on a first-line bevacizumab, oxaliplatin and fluoropyrimidine containing regimen.

How to take it

Adults: Non-small cell lung cancer: 10 mg/kg IV infused over 1 hr prior to docetaxel (75 mg/m²) IV infusion on day 1 of a 21-day cycle. Gastric cancer: Single agent or in combination with paclitaxel: 8 mg/kg IV q2wk; infuse over 1 hr. Paclitaxel dose (if given in combination): 80 mg/m² once weekly for 3 weeks of every 28-day cycle. When given in combination, administer ramucirumab prior to administration of paclitaxel. Colorectal cancer: 8 mg/kg IV q2wk; administer by IV infusion over 60 minutes prior to FOLFIRI administration. Administer diluted Ramucirumab infusion via infusion pump over 1 hr through a separate infusion line. Use of a protein sparing 0.22 micron filter is recommended.…

Side effects

Fatigue, asthaenia, neutropenia, diarrhoea, epistaxis, peripheral edema, stomatitis, proteinuria, hypertension, Infusion-related reactions, hypertension grade 3-4, thrombocytopenia, hypoalbuminaemia.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Precautions: Hemorrhage, gastrointestinal perforation, impaired wound healing.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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