Claribin

by Saibins

Active ingredient: Clarithromycin

Packs

About Clarithromycin

Macrolide & similar types

Uses

Lower and upper respiratory tract infections: tonsillitis, pharyngitis, sinusitis, bronchitis, community acquired pneumonia. Skin and soft tissue infections, acute otitis media, mycobacterium avium infections.

How to take it

ORAL: Adults: 500 mg once daily or 250 mg twice daily with food for 7 to 14 days. Severe infections, 500 mg twice daily. Children: All twice daily. Under 1 yr, 7.5 mg/kg; 1-2 yr, 2.5 mL (62.5 mg); 3-6 yr, 5 mL (125 mg); 7-9 yr, 7.5 mL (187.5 mg); 10-12 yr, 10 mL (250 mg). Lower Respiratory Tract Infections: Adults: 250-500 mg every 12 hr for 7-14 days. Children:> 6 mth: 7.5 mg/kg every 12 hr for 10 days. Upper Respiratory Tract Infections: Adults: Pharyngitis/Tonsillitis: 250 mg every 12 hr for 10 days. Sinusitis: 500 mg every 12 hr for 14 days. Children: > 6 mth: Pharyngitis/Tonsillitis/Sinusitis: 7.5 mg/kg every 12 hr for 10 days. INJECTION: Adults & Children: Over 12 yr: By IV, 500 mg…

Side effects

GI upset, paraesthesia, stomatitis, glossitis, oral monilia, tongue or tooth discolouration, headache, arthralgia, myalgia, rash, transient CNS effects, allergic reactions, hepatic dysfunction, reversible hearing loss. Rarely, pseudomembranous colitis, hypoglycaemia, leucopenia, thrombocytopenia, renal dysfunction, QT prolongation, vasodilation, hyperhidrosis, insomnia, headache, dysgeusia, C.difficile associated diarrhoea.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: History of QT prolongation, arrhythmia, hypokalaemia, severe hepatic failure, renal impairment. Precautions: Renal or hepatic impairment. Presence of or predisposition to QT prolongation. History of arrhythmias. Myasthenia gravis.

Advice

Take tablet or suspension with or without meals. Take extended release preparations with meals. Do not crush or chew extended release tablets. Contact prescriber if there is palpitations, rapid heartbeat, constant fever or chills, easy bleeding or bruising, joint pain, severe constant diarrhoea, nausea, skin rash, itching, mouth sores, foul-smelling urine or difficulty in breathing. Watery or bloody stools can occur 2 or more months after therapy and can be serious, requiring immediate treatment. Complete full course of therapy even if you feel better. Avoid refrigerating oral suspension. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the…

Full information on Clarithromycin →

Interactions with Clarithromycin

Cisapride, ergot derivatives, theophylline, oral anticoagulants, digoxin, pimozide, CYP3A4 inducers, protease inhibitors, zidovudine, NNRTIs, statins, rifabutin, midazolam, alprazolam, cyclosporin, colchicine, eplerenone, eletriptan, sirolimus, tacrolimus, PDE5 inhibitors, cilostazol, vinblastine, methylprednisolone, omeprazole, atypical antipsychotics, itraconazole, valproate, calcium channel blockers, aminoglycosides, other ototoxic drugs, insulin, oral hypoglycaemics, tolterodine, antiarrhythmics, ticagrelor, ranolazine, oral contraceptives.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.