Ceftifixe

by Synchro

Active ingredients: Cefotaxime, Cefotaxime sodium

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About Cefotaxime

Cephalosporin

Uses

Infections of the respiratory tract, kidney, urinary tract and reproductive organs, including gonorrhoea, septicaemia, endocarditis, meningitis. Infections of bone, joint, soft tissues and skin. Abdominal infections, infections of ear and throat. Infected burns and wounds. Infections in gynaecology and obstetrics. For treatment or prophylaxis of in patients with reduced resistance (dose and number of infections depend on the clinical picture and the local resistance situation).

How to take it

Adults: 1 gm IV or IM every 12 hr; serious infections, 3-6 gm daily in three or four divided doses; max 12 gm daily. Use 2 gm by IV route. Children: Neonates, 50 mg/kg daily; others, 100-150 mg/kg daily. Both in two to four divided doses; max 200 mg/kg daily. Bone Infection: IM/IV: Adults & Children: >50 kg: 1-2 gm every 8 hr. Max: 12 gm/day. Children: 1 mth-12 yr: <50 kg: 50-180 mg/kg/day divided into 4-6 doses. 1-4 wk: 50 mg/kg IV every 8 hr. 0-1 wk: 50 mg/kg IV every 12 hr. Meningitis: IV: Adults & Children: >50 kg: 2 gm every 6-8 hr. Max: 12 gm/day. Children: 1 mth-12 yr: <50 kg: 50-180 mg/kg/day divided into 4-6 doses. 1-4 wk: 50 mg/kg IV every 8 hr. 0-1 wk: 50 mg/kg IV every 12 hr.…

Side effects

Pain at inj site, phlebitis, hypersensitivity reactions. GI upset, candidiasis, eosinophilia, neutropenia, leucopenia, granulocytopenia, agranulocytosis, thrombocytopenia, haemolytic anaemia, raised liver enzymes. Rarely, pseudomembranous colitis. Risk of encephalopathy and changes in renal function with high doses. Positive Coomb's test.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Precautions: Penicillin sensitivity. Severe renal failure. Monitor blood count if treatment exceeds 10 days.

Advice

Contact prescriber if there is burning/swelling/redness/pain at injection or infusion site or rash, hives, itching, difficulty in breathing or swallowing, severe unrelieved diarrhoea, vaginal drainage or itching, mouth sores, blood/pus/mucus in stool or urine, unusual chills or fever occur. Watery or bloody stools can occur 2 or more months after therapy and can be serious, requiring immediate treatment. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.

Full information on Cefotaxime →

Interactions with Cefotaxime

Loop diuretics, aminoglycosides, probenecid.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.