Carapine

by Caraway

Active ingredient: Clozapine

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About Clozapine

Tranquilizer, Sedative/Hypnotic

Uses

Treatment-resistant schizophrenia in patients unresponsive to or intolerant of conventional neuroleptics.

How to take it

Adults: Day 1: 12.5 mg once or twice daily; day 2, 25 mg once or twice daily. Increase by 25-50 mg daily, over two to three wk, to 300 mg daily in divided doses. If necessary, continue to increase by 50-100 mg increments at 4-7 day intervals, up to max dose of 900 mg daily. Maintenance: 150-300 mg daily in divided doses. If treatment break exceeds 2 days re-titrate from initial dose. Elderly: Initially 12.5 mg daily increasing gradually in increments of 25 mg daily. Children: Not recommended.

Side effects

Leucopenia, neutropenia, agranulocytosis, anaemia, eosinophilia, leukocytosis, wt gain, drowsiness, dizziness, blurred vision, headache, tremor, rigidity, akathisia, extrapyramidal reactions, seizures, myoclonic jerks, tachycardia, ECG changes, hypertension, postural hypotension, syncope, constipation, hypersalivation, anorexia, GI upset, dry mouth, raised liver enzymes, urinary incontinence, urinary retention, fatigue, fever, disturbed temperature regulation, dysarthria. Reports of impaired peristalsis, falls caused by seizures, somnolence, postural hypotension, motor and sensory instability.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: History of drug induced neutropenia/agranulocytosis or myeloproliferative disorders. Alcoholic and toxic psychosis, drug intoxication, comatose states, circulatory collapse, CNS depression, severe hepatic or renal disease, cardiac failure, paralytic ileus. Myelosuppression, uncontrolled epilepsy. Precautions: Monitor leukocyte counts prior to treatment, then weekly during weeks 1-18, fortnightly for weeks 19-52, then every 4 weeks thereafter; withdraw immediately if WBC count below 3 x 10^9/l or neutrophil count below 1.5 x 10^9/l. Patients should report symptoms of infection. Use…

Advice

Take with or without meals. Open the blister pack of disintegrating tablets only when you are ready to take the tablet. Peel back the foil and do not push tablet through the foil because doing so could damage the tablet. Place the tablet on tongue without breaking it and let it dissolve. Water is not needed. If you stop taking medication for more than 2 days, consult prescriber because dosage may need to be changed. Contact prescriber if there is fatigue, fever, sore throat, weakness, difficulty in breathing, changes in vision, increased saliva, depression, lack of sleep, change in consciousness, severe dizziness, fast heartbeat, palpitations, increased sweating, increased tearing or if…

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Interactions with Clozapine

Myelosuppressants, depot antipsychotics, centrally acting agents, lithium, CNS depressants, narcotic analgesics, alcohol, MAOIs, benzodiazepines, antihistamines, valproic acid, anticholinergics, hypotensives, respiratory depressants, adrenaline, nor adrenaline, cimetidine, erythromycin, fluvoxamine, SSRIs, azole antifungals, venlafaxine, protease inhibitors, carbamazepine, phenytoin, rifampicin, omeprazole, TCADs, phenothiazines, class 1c antiarrhythmics, digoxin, warfarin, inducers and inhibitors of CYP1A2, drugs that prolong QT interval or cause electrolyte imbalance.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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