Calent

by Genix

Active ingredients: Co-careldopa, Entacapone

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About Co-careldopa

Antiparkinsonism Preps

Uses

Idiopathic, post encephalitic and arteriosclerotic Parkinsonism.

How to take it

Parkinson's disease: Adults: Patients not receiving levodopa, initially carbidopa 12.5 mg plus levodopa 50 mg or carbidopa 25 mg plus levodopa 100 mg three times daily, increasing by 12.5/50 mg or 25/100 mg daily or on alternate days to 200/800 mg daily. Children: Not recommended.

Side effects

Cardiac and CNS disturbances, GI upset, anorexia, BP change, psychiatric disorders, dystonia, wt change, anaemia, skin reactions, hyperhidrosis, alopecia, peripheral oedema, dry mouth, dyspnoea, oropharyngeal pain, aspiration pneumonia, dysgeusia, fatigue, asthenia, urinary retention and incontinence, neck pain, vit B6/B12 deficiency, increased blood homocysteine, complications of tube insertion. Urine discolouration.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Severe psychosis, narrow angle glaucoma, history of malignant melanoma. Precautions: Cardiovascular, hepatic, renal, pulmonary or endocrine disease, recent MI. History of psychosis. Monitor for mental changes, depression and suicidal ideation. Peptic ulceration, history of convulsions, wide angle glaucoma. Monitor blood values, hepatic, renal and cardiovascular function. Risk of sudden sleep onset and dopamine dysregulation syndrome. Monitor for impulse control disorders incl pathological gambling, hypersexuality, compulsive spending or eating. Withdraw gradually.

Advice

Take atleast 30 minutes before meals. To reduce GI upset, take with meals. Take at the same time each day. Do not crush sustained release form. Contact prescriber if there is unrelieved constipation, vomiting, acute headache, dizziness, chest pain, irregular heartbeat, nervousness, loss of memory, hallucinations, seizures, painful or difficult urination, skin rash, increased muscle spasm, rigidity or involuntary movements, abdominal pain, blood in stool or if there is worsening of condition. Do not take OTC sedatives and CNS depressants without consulting prescriber. Avoid alcohol during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted…

Full information on Co-careldopa →

Interactions with Co-careldopa

Drugs affecting central amines. MAOIs. Antihypertensives and sympathomimetics, ferrous sulphate, TCADs, dopamine antagonists, anticholinergics.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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