Cadegran

by Safe

Active ingredient: Granisetron

Packs

About Granisetron

Antiemetic & Gastroprokinetic

Uses

Prevention of cytostatic or radiotherapy induced nausea and vomiting, prevention of post-operative nausea and vomiting. Treatment of post-operative nausea and vomiting.

How to take it

ORAL: Adults: 1 mg twice daily or 2 mg once daily, initial dose administered one hr prior to cytostatic therapy. Children: Not recommended. INFUSION: Cytostatic induced nausea and vomiting: Adults: Usually 3 mg diluted in 20-50 mL infusion fluid administered by IV infusion over 5 min or diluted in 15 mL infusion fluid administered by IV bolus Inj over 30 sec. If necessary repeat at intervals of at least 10 min; max 9 mg in 24 hr. Children: 40 mcg/kg (upto 3 mg) diluted in 10-30 mL infusion fluid administered by IV infusion over 5 min. If necessary repeat once within 24 hr at least 10 min after initial infusion. Prevention of post-operative nausea and vomiting: Adults: 1 mg diluted to 5 mL…

Side effects

Headache, insomnia, GI upset, constipation, asthaenia, pain. Transient rise in liver enzymes. Reports of serotonin syndrome.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Precautions: Subacute intestinal obstruction. Cardiac disease, cardiotoxic chemotherapy, electrolyte abnormalities. Hepatic or renal impairment.

Advice

Take tablets without meals. Patients wearing granisetron patch should cover it with cloth if there is a risk of exposure to sunlight. After removal of patch, continue covering application site for 10 days. Contact prescriber if there is constipation, fever, severe diarrhoea or severe headache.

Full information on Granisetron →

Interactions with Granisetron

CYP1A1 or CYP3A4 inhibitors or inducers. Other serotonergic drugs. Drugs that prolong QT interval.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.