Blaze

by Mass/Pharma Health

Active ingredient: Losartan potassium

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About Losartan

Angiotensin-II Antagonist

Uses

Hypertension. Diabetic nephropathy in type 2 diabetes mellitus.

How to take it

Adults: Hypertension: 50 mg once daily. If necessary increase to max 100 mg once daily. With intravascular volume depletion (adults 18-75 yrs), 25 mg once daily for several wks, increased up to 100 mg once daily if necessary. Elderly: Over 75 yr, initially 25 mg once daily. Children: Under 6 yr, not recommended. Hypertension: 6-18 yr, body-weight less than 50 kg, initially 700 mcg/kg (max 25 mg) once daily (lower dose in intravascular volume depletion), adjusted according to response, max 50 mg once daily; Body-weight 50 kg and over, initially 50 mg once daily (initially 25 mg once daily in intravascular volume depletion), adjusted according to response, max 1.4 mg/kg (max 100 mg) once…

Side effects

Dizziness, orthostatic effects, diarrhoea, liver function abnormalities, myalgia, migraine, urticaria, pruritus, rash. Rarely, anaphylactic reactions, angioedema, vasculitis, hepatitis, cough, anaemia, hypotension, renal impairment, increased blood urea, creatinine, potassium.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Renal arteries stenosis, severe hepatic impairment. Precautions: History of angioedema. Hepatic impairment, renal impairment, intravascular volume depletion, renal artery stenosis, kidney transplantation, primary aldosteronism, severe heart failure, arrhythmias, obstructive valvular disease, aortic stenosis, outflow obstruction, cardiomyopathy. Monitor serum potassium in the elderly and in renal impairment.

Advice

Take with or without meals. Preferably, it should be taken on empty stomach 1 hour before or 2 hours after meals. Contact prescriber if there is prolonged diarrhoea, nausea or vomiting, chest pain, palpitations, unrelieved headache, back pain, muscle pain, weakness, delusions, depression or swelling of face/mouth/tongue/throat. Do not take potassium supplements or salt substitutes without consulting prescriber. Avoid exercising in hot weather, avoid excessive intake of alcohol. Change position slowly when climbing stairs and from lying or sitting to standing position.

Full information on Losartan →

Interactions with Losartan

K+ -sparing diuretics, K+ supplements, rifampicin, fluconazole, NSAIDs, other antihypertensives, lithium, heparin.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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