Bevacirel

by Helix

Active ingredient: Bevacizumab

Packs

About Bevacizumab

Cytostatic

Uses

Metastatic Colon/Rectum Carcinoma. Persistent/recurrent/metastatic cervical cancer, glioblastoma, non-small cell lung cancer, ovarian (epithelial), fallopian tube, or primary peritoneal cancer (platinum-resistant recurrent/platinum-sensitive recurrent), metastatic renal cell cancer.

How to take it

Metastatic Colon/Rectum Carcinoma: Adults: 5 mg/kg IV infusion over 90 min once every 14 days until disease progression is detected. If 1st infusion is well tolerated, administer 2nd infusion over 60 min. If 2nd infusion is well tolerated, administer subsequent doses over 30 min. Persistent/recurrent/metastatic cervical cancer: Adults: 15 mg/kg every 3 wks (in combination with paclitaxel and either cisplatin or topotecan) until disease progression or unacceptable toxicity. Glioblastoma: Adults: 10 mg/kg every 2 wks as a single agent until disease progression or unacceptable toxicity. Non-small cell lung cancer: Adults: 15 mg/kg every 3 wks (in combination with carboplatin and paclitaxel)…

Side effects

GI perforation or fistulae, tumour-associated and mucocutaneous hemorrhage, arterial and venous thromboembolism, HTN, proteinuria, CHF, immune system disorders, hypersensitivity and infusion reactions, hypertension, asthenia, fatigue, wt loss, blood dyscrasias, peripheral sensory neuropathy, anorexia, dysgeusia, dysphonia, headache, eye disorders, increased lacrimation, dyspnoea, epistaxis, cough, rhinitis, stomatitis, skin reactions, arthralgia, pyrexia, pain, mucosal inflammation, infections, dehydration, stroke, syncope, somnolence, supraventricular tachycardia, electrolyte disturbances, hypoxia, GI upset, ileus, GI obstruction, proctalgia, myalgia, muscle weakness, lethargy, dysarthria,…

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Hypersensitivity to Chinese hamster ovary cell products or other recombinant human or humanised antibodies. Renal or hepatic impairment. Recent pulmonary haemorrhage/haemoptysis. Precautions: Increased risk for development of GI perforation. Increased risk of HTN; temporarily discontinue until HTN is controlled. Hypertensive crisis, development of arterial and thromboembolic events and pulmonary embolism; discontinue use. Preexisting CAD or CHF. May adversely affect wound healing process. Initiate therapy only atleast 28 days following major surgery or until surgical wound is fully healed.…

Advice

Contact prescriber if there is severe headache, vomiting, chest pain, numbness of arms or legs, confusion, impaired speech, difficulty in breathing, blood with cough, changes in vision, dark coloured stools, difficulty in urination, swelling on lips/throat/face/eyelids. Avoid alcohol during therapy. Avoid activities that may cause bruising or injury. If a dose is missed, immediately inform prescriber to make a new dosing schedule. Keep all doctors and laboratory appointments.

Full information on Bevacizumab →

Interactions with Bevacizumab

Irinotecan, sunitinib, IV bisphosphonates, EGFR, monoclonal antibodies.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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