Actilyse

by Martin Dow Marker

Active ingredient: Alteplase

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About Alteplase

Anticoagulant/Antiplatelet

Uses

Acute myocardial infarction, pulmonary embolism, acute ischaemic stroke.

How to take it

Adults: Myocardial infarction: Accelerated regimen (initiated within 6 hr of symptom onset): 15 mg by IV inj, followed by IV infusion of 50 mg over 30 min, then 35 mg over 60 min (total dose 100 mg over 90 min). In patients < 65 kg, 15 mg by IV inj, followed by IV infusion of 0.75 mg/kg over 30 min, then 0.5 mg/kg over 60 min (max total dose 100 mg over 90 min). Myocardial infarction, initiated within 6-12 hr of symptom onset: 10 mg by IV inj, followed by IV infusion of 50 mg/kg over 60 min, then 4 infusions each of 10 mg over 30 min (total dose 100 mg over 3 hr; max 1.5 mg/kg in patients less than 65 kg). Pulmonary Embolism: 10 mg by IV inj over 1-2 min, followed by IV infusion of 90 mg…

Side effects

Risk of cerebral bleeding, nausea, vomiting, reperfusion arrhythmias and recurrent ischaemia and angina, hypotension, back pain, fever, convulsion.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Recent haemorrhage, trauma, surgery, coagulation defects, bleeding diatheses, aortic dissection, aneurysm, coma, history of cerebrovascular disease, peptic ulceration, heavy vaginal bleeding, severe hypertension, active pulmonary disease, acute pancreatitis, pericarditis, bacterial endocarditis and oesophageal varices. Acute stroke, convulsion accompanying stroke, history of stroke in patients with diabetes, stroke in last 3 months, hypoglycaemia, hyperglycaemia. Precautions: Acute stroke, monitor for intracranial haemorrhage, monitor blood pressure. Use with caution if there is risk…

Advice

Immediately report bleeding, including from the nose or gums. To reduce the risk of injury and bleeding, take strict bed rest and limit physical activity. Use electric razor and soft toothbrush. Be cautious while using knives, needles or sharp things. To stop bleeding, apply pressure to the bleeding spot until bleeding stops completely. Contact prescriber if there is acute headache; joint pain; chest pain; unusual bruising or bleeding; blood in urine, stool or vomit; bleeding in gums; vision changes or respiratory difficulty.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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