Zyloric

by GSK

Active ingredient: Allopurinol

PKR 38

Available at Healify

Zyloric Tablets 100Mg (1 Strip = 10 Tablets) · Strip · PKR 38 · In stock · Prescription medicine
Zyloric Tablets 300Mg (1 Box = 3 Strips) (1 Strip = 10 Tablets) · Box · PKR 276 · In stock · Prescription medicine

Manufactured by GLAXO SMITH KLINE PAKISTAN.

About Allopurinol

Anti-gout Preparations

Uses

For the main clinical manifestations of urate/uric acid deposition. These are gouty arthritis, skin tophi and/or renal involvement through crystal deposition or stone formation. Such clinical manifestations occur in: Idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myelo-proliferative disease after cytotoxic therapy; and certain enzyme disorders which lead to over-production of urate.

How to take it

The dosage should be adjusted by monitoring serum urate concentrations and urinary urate/uric acid levels at appropriate intervals. Dosage frequency: Once a day after a meal or after food. Should the daily dosage exceed 300 mg and gastrointestinal intolerance be manifested, a divided doses regimen may be appropriate. Adults: 2 to 10 mg/kg body wt/day or 100 to 200 mg daily in mild conditions; 300 to 600 mg daily in moderately severe conditions; 700 to 900 mg daily in severe conditions. Children: Prophylaxis of hyperuricaemia associated with cancer chemotherapy, prophylaxis of hyperuricaemic nephropathy, enzyme disorders causing increased serum urate e.g. Lesch-Nyhan Syndrome: 1 mth-15 yr,…

Side effects

Skin reactions; withdraw if occur. Nausea. Acute gout, raised TSH.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Acute gout. Precautions: Elderly. Renal or hepatic dysfunction, hypertension, cardiac insufficiency, thyroid disorders. When initiating therapy give also colchicine or an anti- inflammatory agent for 1 month. Ensure adequate fluid intake.

Advice

Take immediately after meals. Contact prescriber if there is unrelieved nausea or vomiting, skin rash/lesions, pain on urination, blood in urine or stool, numbness of extremities, pain or irritation of the eyes, swelling of mouth/lips/tongue, easy bruising or bleeding, unusual fatigue, change in colour of urine or stool, yellowing of skin or eyes. Avoid alcohol during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.

Full information on Allopurinol →

Interactions with Allopurinol

Anticoagulants, chlorpropamide, mercaptopurine or azathioprine, ampicillin, amoxicillin, salicylates, cyclophosphamide, other cytotoxics, theophylline, cyclosporin, phenytoin, didanosine, aluminium hydroxide, diuretics, ACE inhibitors.

Tell your pharmacist or doctor about every medicine you take, including herbal products.