Zafridat

by Zafa

Active ingredient: Trimebutine maleate

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About Trimebutine Maleate

Antispasmodic & Anticholinergic

Uses

Smooth muscle spasm.

How to take it

Adults: 200 mg three times daily. Max 600 mg daily. Children: Not recommended.

Side effects

Constipation, transient bradycardia (followed by tachycardia, palpitation and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatation of the pupils with loss of accommodation, photophobia, dry mouth, flushing and dryness of the skin. Side-effects that occur occasionally include confusion (particularly in the elderly), nausea, vomiting and giddiness. Very rarely, angle-closure glaucoma may occur.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Antimuscarinics are contra-indicated in Myasthaenia gravis (but may be used to decrease muscarinic side-effects of anticholinesterases), paralytic ileus, pyloric stenosis, toxic megacolon and prostatic enlargement. Coma, stupor, iodine sensitivity. Precautions: Antimuscarinics should be used with caution in Down's syndrome, in children and in the elderly; they should also be used with caution in gastro-esophageal reflux disease, diarrhoea, ulcerative colitis, autonomic neuropathy, acute myocardial infarction, hypertension, conditions characterised by tachycardia (including…

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Interactions with Trimebutine Maleate

Amantadine, atenolol, digoxin, phenothiazines, tricyclic antidepressants.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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