Variba

by Bosch

Active ingredient: Ribavirin

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About Ribavirin, Oral

Antiviral, Systemic

Uses

Severe respiratory syncytial virus bronchiolitis in infants and children; in combination with peginterferon alfa-2b or interferon alfa for chronic hepatitis C not previously treated in patients without liver decompensation and who have fibrosis or high inflammatory activity or for relapse following previous response to interferon alfa.

How to take it

Chronic hepatitis C: Adults: over 18 yr, body-weight under 65 kg, 400 mg twice daily; body-weight 65-85 kg, 400 mg in the morning and 600 mg in the evening; body-weight over 85 kg, 600 mg twice daily. Children: 15-20 mg/kg body weight daily in three divided dosage for 5-7 days.

Side effects

Haemolytic anaemia; also reported (in combination with peginterferon alfa-2b or interferon alfa-2b), nausea, vomiting, dry mouth, stomatitis, glossitis, dyspepsia, abdominal pain, diarrhoea, constipation, pancreatitis, anorexia, weight loss; chest pain, tachycardia, syncope, flushing; dyspnoea, cough, rhinitis, pharyngitis; sleep disturbances, asthaenia, impaired concentration, irritability, aggression, anxiety, depression, dizziness, tremor, hypertonia, myalgia, arthralgia, paraesthesia, influenza-like symptoms, headache; thyroid disorders, menstrual disturbances, reduced libido; rash, pruritus, photosensitivity, alopecia, dry skin; taste disturbance, blurred vision, tinnitus; neutropenia,…

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe cardiac disease, including unstable or uncontrolled cardiac disease in previous 6 months; haemoglobinopathies; severe debilitating medical conditions; renal impairment; severe hepatic dysfunction or decompensated cirrhosis; autoimmune disease (including autoimmune hepatitis); history of severe psychiatric condition. Precautions: Exclude pregnancy before treatment; effective contraception essential during treatment and for 4 months after treatment in women and for 7 months after treatment in men; routine monthly pregnancy tests recommended; condoms must be used if partner of male…

Advice

Tablets: Take with meals. Capsule/Solution/Syrup: Take with or without meals in a constant manner (always with meals or always without meals). When capsules are to be taken in combination with peginterferon alfa 2b, take with meals. Contact prescriber if there is fever, chills, rash, unusual bruising or bleeding, unhealed sores, infection, white plaques in mouth, weakness/tingling/pain in extremities. Regular blood tests are required during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Avoid highly crowded places to prevent infections. Do not get vaccinated without consulting prescriber.

Full information on Ribavirin, Oral →

Interactions with Ribavirin, Oral

NRTIs, azathioprine.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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