Tuximab

by Searle

Active ingredient: Rituximab

Packs

About Rituximab

Cytostatic

Uses

Relapsed or chemoresistant stage III-IV follicular lymphoma. In combination with CVP chemotherapy for untreated stage III-IV follicular lymphoma. In combination with CHOP chemotherapy for CD20 positive diffused large B cell non-Hodgkin's lymphoma.

How to take it

Adults: Follicular lymphoma as single agent: 375 mg/m² by IV infusion once weekly for 4 wk. Follicular lymphoma with CVP: 375 mg/m² by IV infusion for 8 cycles on Day 1 of each chemotherapy cycle after corticosteroid component of CVP. Large B-cell lymphoma: 375 mg/m² by IV infusion on Day 1 of each chemotherapy cycle for 8 cycles after corticosteroid component of CHOP. See literature. Children: Not recommended. Do not administer as an IV push or bolus. Interrupt rituximab infusion for severe reactions and resume at a 50% reduction in rate (e.g. from 100 to 50 mg/hours) when symptom have completely resolved. In most cases, patients who have experienced nonlife-threatening reactions have been…

Side effects

Headache, fever, chills, nausea, leucopenia, pruritus, rash, neutropenia, thrombocytopenia, anaemia, rhinitis, diarrhoea, dyspepsia, agitation, insomnia, nervousness, bronchitis, severe vision loss, hearing loss, loss of other senses, HTN, Hypercholesterolaemia, migraine, UTI, inf-related reactions, angioedema, infections, blood dyscrasias, GI upset, anorexia, skin reactions, alopecia, asthenia, decreased IgG levels, hyperglycaemia, wt loss, oedema, increased LDH, hypocalcaemia, paraesthesia, hypoaesthesia, vasodilatation, dizziness, anxiety, conjunctivitis, lacrimation disorder, tinnitus, ear pain, cardiovascular events, cardiac disorders, hypertension, bronchospasm, respiratory disease,…

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Active hepatitis B infection. Severely immunocompromised state. Hypersensitivity to murine proteins. Acute, severe infection. Precautions: Patients with a high number (>25000 mm³) of circulating malignant cells or high tumour burden e.g. CLL and Mantle cell lymphoma; history of pulmonary insufficiency, pulmonary tumour infiltration. Withhold antihypertensive medications 12 hrs prior to and throughout infusion. History of cardiac disease. Neutrophil count <1.5x/10^9L and/or platelet count <75x10^9/L. Infusion reaction, infection. Immunization. Progressive multifocal leukoencephalopathy. Use…

Advice

This medication is administered by infusion. Contact prescriber if there is fever, chills, fatigue, wheezing, shortness of breath, unrelieved GI disturbances, persistent dizziness, swelling of extremities, chest pain, chest tightness, skin rash, skin redness, sore throat, irritated throat, unhealed sores, unusual weight gain, difficulty in breathing, unusual bruising or bleeding, white plaques in mouth or genital area. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Avoid highly crowded places to prevent infection. People around you should wear mask and gloves. Do not get vaccinated without consulting prescriber. Close…

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Interactions with Rituximab

Vaccines.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.