Topotecan Medac

by Amgomed

Active ingredient: Topotecan

Packs

About Topotecan

Cytostatic

Uses

Metastatic ovarian cancer where other therapies have failed. Treatment of recurrent or resistant (stage IVB) cervical cancer (in combination with cisplatin) which is not amenable to curative treatment. Relapsed small cell lung cancer.

How to take it

Injection: Adults: Ovarian cancer, metastatic: 1.5 mg/m² daily by IV infusion over 30 min for 5 consecutive days. Repeat every 3 wk for minimum of 4 courses. Cervical cancer, recurrent or resistant: 0.75 mg/m²/day for 3 days via IV route (in combination with cisplatin on day 1 only, [with hydration]) every 21 days. Small cell lung cancer, relapsed: 1.5 mg/m²/day via IV route for 5 consecutive days every 21 days. Oral: Adults: Ovarian cancer, metastatic: 2.3 mg/m² daily for 5 consecutive days every 21 days. Small cell lung cancer, relapsed: 2.3 mg/m²/day for 5 consecutive days every 21 days (round dose to the nearest 0.25 mg); if patient vomits after dose is administered, do not give a…

Side effects

Neutropenia, thrombocytopenia, anaemia, abdominal pain, fatigue, asthaenia, infection, sepsis, blood dyscrasias, rash, GI upset, mucositis, anorexia, hyperbilirubinaemia, alopecia, pruritus, pyrexia, malaise.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Haemoglobin <9g/dl. Severe renal (CrCl <20m1/min) or hepatic impairment. Severe myelosuppression (baseline neutrophils <1.5 x 109/l and/or platelets <100 x 109/1). Precautions: Renal or hepatic impairment. Mild to moderate renal impairment. Ensure baseline neutrophils as necessary prior to treatment. Monitor blood regularly. Risk factors for interstitial lung disease (ILD). Monitor for symptoms of ILD; discontinue if diagnosis confirmed.

Advice

Take oral forms with or without meals. Do not chew or crush or open capsules. Swallow whole. Report immediately swelling/redness/burning or pain at infusion site. Contact prescriber if there is severe constant fever, chills, cough, odd-smelling urine, pain on urination, unhealed mouth or vaginal sores, easy bruising or bleeding, unusual constant weakness or lethargy, difficulty in breathing, numbness or tingling in fingers and toes, diarrhoea that remains for more than 3 days, diarrhoea with fever or abdominal pain. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Maintain good oral hygiene by rinsing mouth regularly and using…

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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