Theophylline

by Lisko

Active ingredient: Theophylline

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About Theophylline, Oral

Bronchodilator & Anti-asthma Preps: Orals/Parenterals

Uses

Reversible bronchospasm in asthma and COPD.

How to take it

Adults: 175 mg-350 mg twice daily. Children: Under 2 yr, not recommended. 2-6 yr, 60-120 mg; 6-12 yr, 125-250 mg. Both twice daily.

Side effects

Tachycardia, arrhythmias, palpitations, convulsions, GI upset, headache, insomnia, CNS stimulation, hypotension, urinary retention.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Epilepsy, porphyria, concomitant use of ephedrine in children, recent MI, acute tachycardia. Precautions: Cardiac arrhythmia, other cardiovascular disease, CHF, severe asthma, severe renal impairment, peptic ulcer, hyperthyroidism, hypertension, history of seizures, hepatic dysfunction, ECT, viral infections, cystic fibrosis, urinary tract obstruction, acute febrile illness, chronic alcoholism. Elderly.

Advice

Take with or without meals. To reduce GI discomfort, take with meals. Swallow with a full glass of water. Do not chew or crush sustained release forms, swallow whole. If there is difficulty in swallowing capsules, open and sprinkle contents on soft food. Do not chew beads. Contact prescriber if there is fever, fast heartbeat, chest pain, restlessness, lack of sleep, emotional instability, agitation, acute headache, stomach pain, muscle cramps/tremors, dark or black coloured stool or if there is worsening of condition. Avoid smoking during therapy. Inform prescriber if you start or stop smoking, make dietary changes and take any new medication. Avoid tea, chocolate, colas, caffeine during…

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Interactions with Theophylline, Oral

Plasma levels increased by allopurinol, cimetidine, ciprofloxacin, clarithromycin, diltiazem, disulfiram, erythromycin, fluconazole, ketoconazole, fluvoxamine, influenza vaccine, interferon, acyclovir, oral contraceptives, methotrexate, mexiletine, nizatidine, quinolones, pentoxyfylline, propafenone, propranolol, verapamil, ticlodipine, rofecoxib, BCG vaccine. Plasma levels decreased by carbamazepine, primidone, phenytoin, rifampicin, ritonavir, sulfinpyrazone, barbiturates, smoking, St. John's Wort. Other interactions: beta-agonists, adenosine, benzodiazepines, diuretics, ketamine, halothane, lithium, corticosteroids, B blockers, caffeine, doxapram, imipenem, isoniazid, ranitidine,…

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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