Sedectil

by Usawa

Active ingredients: Chlorpromazine, Phenothiazine

Packs

About Chlorpromazine

Tranquilizer, Sedative/Hypnotic

Uses

CNS disturbances requiring sedation; pre-medication; induction of hypothermia, emesis; schizophrenia; affective disorders.

How to take it

Adults: To manage symptoms of psychotic disorders or control manic manifestations of manic-depression: ORAL: 10 mg t.i.d or q.i.d, 25 mg b.i.d or t.i.d. After 1 or 2 days, dose increased by 20-50 mg semi-weekly until patient is calm. After 2 wk, dosage gradually reduced to maintenance dose 200-800 mg daily in divided doses. Nausea & vomiting: ORAL: 10-25 mg every 4-6 hrs, p.r.n. INJECTION: IM: 25 mg. If no hypotension occurs, 25-50 mg every 3-4 hrs, p.r.n, until vomiting stops; then drug switched to oral form. Intractable hiccups: ORAL: 25-50 mg every 6-8 hrs. INJECTION: IM: 25-50 mg every 6-8 hrs. IV: Refractory to oral or IM treatment: 25-50 mg by slow IV infusion. Intraoperative control…

Side effects

Leucopenia, hyperprolactinaemia, acute dystonias and dyskinesias, akathisia, Parkinsonism, drowsiness, insomnia, agitation, tachycardia, arrhythmias, ECG changes, hypotension, anticholinergic effects (e.g. dry mouth, blurred vision), respiratory depression, nasal stuffiness, rash, photosensitivity, hypoglycaemia, impaired temperature regulation, convulsions, male sexual dysfunction. Rarely, agranulocytosis, tardive dyskinesia, jaundice, neuroleptic malignant syndrome, pigmentary retinopathy.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Comatose state. Bone marrow depression. Precautions: Liver dysfunction. Cardiovascular diseases. Parkinsonism, epilepsy.

Advice

Take with or without meals. To reduce GI upset, take with meals. Do not crush, break or chew extended release capsules, swallow whole. Dilute oral concentrate in atleast 4 ounce of fluid just before taking it. Use tomato or fruit juice, milk, simple syrup, orange syrup, a carbonated beverage, coffee, tea, water, or semisolid food, such as pudding and soup. Do not take medication within 2 hours of taking an antacid. Contact prescriber if there is severe dizziness, fast heartbeat, chest pain, palpitations, skin rash, skin irritation, change in urinary pattern, change in menstrual pattern, change in sexual ability, change in gait, change in vision, change in colour of skin (gray-blue),…

Full information on Chlorpromazine →

Interactions with Chlorpromazine

Adrenaline, alcohol, barbiturates, CNS depressants, other antipsychotics, anticholinergics, antacids, dopaminergics, lithium, oral hypoglycaemics, antihypertensives, anticonvulsants, desferrioxamine, propranolol, drugs that prolong the QT interval (e.g. anti-arrhythmics), myelosuppressive drugs, metoclopramide.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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