Rosetum

by Rasco

Active ingredient: Cefoperazone sodium

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About Cefoperazone

Cephalosporin

Uses

Serious bacterial infections of proved or presumed origin from difficult gram-negative bacteria or from mixed flora in the presence of gram-negative germs resistant to the most common antibiotics.

How to take it

Adults: 1-2 gm twice daily IM or IV. By IV adult dose may be doubled. Max 9 gm daily in divided doses. Children & Infants: 50-200 mg/kg/day given in two or more administrations. For neonates (less than 8 days), the drug should be given every 12 hr. IM: Inject deep IM Into large muscle mass. IV: Inject direct IV over 3-5 min. Infuse intermittent infusion over 30 min. IV Detail: pH 4.5-6.5. Reconstitution: IV: Reconstitute with required amount of diluent. Then further dilute in compatible solution. IM: Reconstitute drug with bacteriostatic water for injection (that contains benzyl alcohol or parabens) or SWFI. After reconstitution, let foam dissipate and inspect the solution to ensure…

Side effects

Diarrhoea, rash, decreased neutrophils, haemoglobin, haematocrit, eosinophilia, increased transaminases.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Precautions: Prolonged use may lead to superinfection. May interfere with haemostasis. May cause colitis.

Advice

Contact prescriber if there is burning/swelling/redness/pain at injection or infusion site or rash, hives, itching, difficulty in breathing or swallowing, severe unrelieved diarrhoea, vaginal drainage or itching, mouth sores, blood, pus/mucus in stool or urine, unusual chills or fever. Avoid alcohol during therapy and for 72 hours after you have taken last dose. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.

Full information on Cefoperazone →

Interactions with Cefoperazone

Probenecid, furosemide, aminoglycoside.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.