Ristases

by Sante

Active ingredient: Cyclosporin

PKR 420

Available at Healify

Ristases Eye Drops 10Ml · pc · PKR 420 · In stock · Prescription medicine

Manufactured by SANTE (PRIVATE) LIMITED.

Other packs (not sold online by Healify)

Eye Drop · 0.05% · 10 mL (075811)

About Cyclosporin

Immunomodulator

Uses

Immunosuppression in organ and bone marrow transplantation; prophylaxis and treatment of graft versus-host disease. Short term treatment of severe atopic dermatitis where conventional therapy ineffective or inappropriate. Severe psoriasis, severe eczema, severe active rheumatoid arthritis where conventional therapy ineffective or inappropriate.

How to take it

Organ transplantations: Used alone, Adults & Children over 3 mth: 10-15 mg/kg by mouth 4-12 yr before transplantations followed by 10-15 mg/kg daily for 1-2 wk postoperatively then reduced gradually to 2-6 mg/kg daily for maintenance (dose should be adjusted according to blood-cyclosporin concentration and renal function); dose lower if given concomitantly with other immunosuppressant therapy; if necessary one-third corresponding oral dose can be given by IV infusion over 2-6 hr. Bone marrow transplantation; prophylaxis and treatment of graft versus-host disease: Adults & Children over 3 mth: 3-5 mg/kg daily by IV infusion over 2-6 hr from day before transplantation to 2 wk postoperatively…

Side effects

Hyperlipidaemia, hyper-uricaemia, hyperkalaemia, hypomagnesaemia, tremor, headache, paraesthesia, hypertension (discontinue if cannot control), GI upset, anorexia, abdominal pain, gingival hypertrophy, hepatic and renal dysfunction, hypertrichosis, muscle cramps, myalgia, fatigue, anaemia, thrombocytopenia, signs of encephalopathy, rash, oedema, weigh gain, malignancies, Iymphoproliferative disorders, infections. Rarely, micro-angiopathic Haemolytic anaemia or haemolytic uraemic syndrome, menstrual disturbances, gynaecomastia, hyperglycaemia, motor polyneuropathy, pancreatitis, muscle weakness, myopathy, optic disc oedema. Risk of benign intracranial hypertension; investigate patients…

Pregnancy and breastfeeding

Contraindications: Lactation. Precautions: Closely monitor renal and liver functions, BP and serum lipids. Hyperkalaemia, hyper-uricaemia, hypomagnesaemia. Avoid excess exposure to UV light. Acute untreated infection. Elderly. Pregnancy.

Full information on Cyclosporin →

Interactions with Cyclosporin

Tacrolimus, other immunosuppressants, barbiturates, carbamazepine, oxcarbazepine, primidone, phenytoin, griseofulvin, trimethoprim, rifampicin, octreotide, orlistat, St. John's Wort, macrolides, azole antifungals, calcium channel blockers, metoclopramide, oral contraceptives, danazol, allopurinol, amiodarone, ursodeoxycholic acid, protease inhibitors, imatinib, nephrotoxic drugs, NSAIDs, vaccines, digoxin, corticosteroids, statins, etoposide, colchicine, K+-sparing diuretics, K+ supplement, ACE inhibitors, angiotensin II antagonists, grapefruit juice, methotrexate, H2 blockers, propafenone, bromocriptine, doxycycline, chloroquine, sulfinpyrazone, terbinafine, bosentan, substrates of CYP3A4…

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