Relidomide

by Helix

Active ingredient: Lenalidomide

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About Lenalidomide

Cytostatic

Uses

In combination with dexamethasone for the treatment of multiple myeloma patients who have received at least one prior therapy.

How to take it

Adults: Initially 25 mg once daily on day 1-21 of repeated 28-day cycle. Adjust dose accordingly. Children: Not recommended.

Side effects

Infections, blood dyscrasias, hypothyroidism, depression, cerebrovascular accident, disturbed balance, venous thromboembolic events, cardiac failure, altered LFTs, urinary retention, joint swelling, renal failure, hepatic failure, toxic epidermal necrolysis.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Precautions: Renal impairment (CrCl < 50 mL/min); monitor renal function. Risk factors for MI, tumour lysis syndrome. Risk factors for thromboembolism; consider prophylactic anti-thrombotic therapy. Risk of liver injury. Monitor hepatic function and perform FBC (including WBC count with differential, platelet, haemoglobin and haematocrit) at base line, weekly for 1st eight weeks and monthly thereafter. Monitor thyroid function. Risk of secondary primary malignancy. Elderly.

Advice

Take with or without meals. Swallow whole with water. Do not open, break or chew capsules. If a dose is missed, take it if you remember within 12 hours otherwise skip this dose and return to normal schedule. Do not take double dose. Contact prescriber if there is unusual bruising or bleeding, dark stools, blood with stools, fever, sore throat, rash, chills, decreased urination, irregular heartbeat, severe nausea, vomiting, diarrhoea, loss of appetite, muscle weakness, cramps, liver problems (pale stool, dark urine, stomach pain, yellowing of skin or eyes, unusual tiredness), red/swollen/blistered/peeling skin (with or without fever), red or irritated eyes, sores in mouth/throat/ nose/eyes.…

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Interactions with Lenalidomide

Other myelosuppressive agents, warfarin, digoxin, hepatotoxic drugs, oral contraceptives, P-gp inhibitors.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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