Rast-EZ
by Tabros
Active ingredients: Atorvastatin, Ezetimibe
Packs
- Tab · 10/10 mg · 10's
- Tab · 10/20 mg · 10's
In stock at Healify — same active ingredient
Always confirm a substitution with your pharmacist.
About Atorvastatin
Hypolipidaemic/Anti-atheroma
Uses
Adjunct to diet in primary hypercholesterolaemia, heterozygous and homozygous familial hypercholesterolaemia, mixed hyperlipidaemia.
How to take it
Adults: Initially 10 mg once daily. Increase as necessary at 4 wk intervals; max 80 mg once daily. Children: Under 10 yr, not recommended. Hyperlipidaemia including familial hypercholesterolaemia: 10-18 yr, initially 10 mg once daily, increased if necessary at intervals of at least 4 wk to usual max 20 mg once daily. Max 80 mg once daily in homozygous familial hypercholesterolaemia.
Side effects
GI upset, headache, myalgia, asthenia, insomnia, dizziness, paraesthesia, fatigue, myalgia, hypoaesthesia, arthralgia, chest and back pain, hyperglycaemia, nasopharyngitis, pharyngolaryngeal pain, epistaxis, pain in extremity, muscle spasms, joint swelling, abnormal LFTs, raised creatine kinase levels. Elevated ALT and CPK levels. Reports of immune-mediated necrotising myopathy.
Pregnancy and breastfeeding
Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Active liver disease, persistent raised liver enzymes. Ensure adequate contraception. Precautions: History of alcohol abuse or liver disease. Perform liver function tests before and during therapy. Advise patients to report unexplained muscle weakness or pain; measure creatine kinase levels, withdraw if >5 × ULN. Renal impairment, hypothyroidism, history of muscle toxicity or muscle disorders, elderly. Interstitial lung disease; advise patients to report symptoms incl dyspnoea, non-productive cough, fatigue, wt loss, fever. Risk of new onset of diabetes; risk factors include…
Advice
Take with or without meals. Take medication at the same time each day. Contact prescriber if there is unrelieved diarrhoea, fever, unusual muscle cramps, weakness, mood changes, memory changes, yellowing of skin or eyes, easy bruising or bleeding, or unusual fatigue. Take missed dose as soon as possible as you remember, unless it is nearly time for the next dose. Do not double the dose. Avoid high intake of grapefruit juice (> 1 litre per day). Take enough amount of fluid (2-3 litre per day) to prevent dehydration, unless advised by prescriber to restrict fluid intake. Laboratory tests are very important during therapy.
Full information on Atorvastatin →
Interactions with Atorvastatin
Cyclosporin, fibrates, azole antifungals, niacin, drugs metabolised by cytochrome P450 3A4, digoxin, erythromycin, oral contraceptives, antacids, warfarin, gemfibrozil, nicotinic acid, protease inhibitors, macrolides, rifampicin, other inhibitors, inducers or substrates of CYP3A4, grapefruit juice, colestipol, antacids, ezetimibe, diltiazem, verapamil, amiodarone, colchicine, with or within 7 days of systemic fusidic acid.
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Compiled by Healify Pharmacy from published drug references. How we compile it →
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