Proluton Depot

by Bayer

Active ingredient: Hydroxyprogesterone caproate

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About Hydroxyprogesterone Caproate

Progestogen

Uses

Habitual and threatened abortion, infertility due to corpus-luteum insufficiency.

How to take it

Adults: Habitual abortion: 250-500 mg IM at wkly intervals. Imminent abortion: 500 mg IM 2-3 times wkly until bleeding ceases. Treatment must be continued with 250 mg IM twice wkly for several wk. Infertility due to corpus-luteum insufficiency: 250 mg IM about 3 days after rise in basal body temp. Children: Not recommended. After preparing the skin, inject IM in the upper outer quadrant of the gluteus maximus. The solution is viscous and oily. Slow injection (over 1 min or longer) is recommended. Apply pressure to the injection site to minimize bruising and swelling. Discard any unused product 5 weeks after 1st use. Reconstitution: Draw up 1 mL of drug into a 3 mL syringe with an 18-gauge…

Side effects

Menstrual disturbances, premenstrual-like syndrome (including bloating, fluid retention, breast tenderness), weight change, nausea, headache, dizziness, insomnia, drowsiness, depression, change in libido; also skin reactions (including urticaria, pruritus, rash and acne), hirsutism and alopecia. Jaundice and anaphylactoid reactions have also been reported.

Pregnancy and breastfeeding

Contraindications: Progestogens should be avoided in patients with a history of liver tumours, with genital or breast cancer (unless progestogen are being used in the management of these conditions), severe arterial disease, undiagnosed vaginal bleeding and acute porphyria. Progestogens should not be used if there is a history during pregnancy of idiopathic jaundice, severe pruritus, or pemphigoid gestations. Precautions: Progestogens should be used with caution in conditions that may worsen with fluid retention e.g. epilepsy, hypertension, migraine, asthma, or cardiac dysfunction and in those susceptible to thromboembolism (particular caution with high dose, history of depression.…

Full information on Hydroxyprogesterone Caproate →

Interactions with Hydroxyprogesterone Caproate

Rifamycin, anticoagulants, antidepressants, antidiabetics, anti-epileptics, antifungals, antivirals, aprepitant, barbiturates, bosentan, cyclosporin, diuretics, dopaminergics, lipid-regulating drugs, muscle relaxants.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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