Plator

by DonValley

Active ingredient: Cilostazol

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About Cilostazol

Vasotherapeutic

Uses

Improvement of maximal and pain-free walking distances in patients with intermittent claudication who do not have rest pain or evidence of peripheral tissue necrosis.

How to take it

Adults: 100 mg twice daily 30 min before or 2 hr after breakfast and evening meal. Dose 50 mg twice daily are used with certain drugs. Children: Not recommended.

Side effects

Headache, diarrhoea, abnormal stools, ecchymosis, oedema, dizziness, palpitation, tachycardia, angina, arrhythmia, ventricular extrasystole, rhinitis, GI upset, anorexia, pharyngitis, rash, pruritus, chest pain, asthaenia. Reports of blood dyscrasias.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe renal impairment, moderate to severe hepatic impairment, congestive heart failure, predisposition to bleeding, history of ventricular tachycardia, multifocal ventricular ectopics or severe tachycardia. QTc prolongation, unstable angina, recent MI or coronary intervention. Precautions: Advise patients to report any episodes of bleeding or bruising. Atrial or ventricular ectopy, atrial fibrillation or flutter, diabetes. Stable coronary disease, monitor closely. Discontinue if evidence of blood dyscrasias. Withdraw 5 days before elective surgery.

Advice

Take 30 minutes before meals or 2 hours after meals. Contact prescriber if there are chest pain, palpitations, unusual heartbeat, swelling of extremities, unusual bleeding, unresolved GI upset or pain, muscle cramps or unusual cough. Avoid grapefruit juice during therapy. Avoid smoking during therapy. Change position slowly. Medicine effectiveness is based on ability to walk increased distances. Medicine effects will not appear until 2 to 4 weeks after therapy starts and full effects may take upto 12 weeks.

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Interactions with Cilostazol

Cimetidine, diltiazem, erythromycin, clarithromycin, ketoconazole, lansoprazole, omeprazole, protease inhibitors, cisapride, midazolam, nifedipine, verapamil, other inhibitors or substrates of CYP3A4 or 2C19. Highly protein bound drugs, hypotensive agents, aspirin, antiplatelets, clopidogrel, anticoagulants, vasodilators, statins, pimozide, ergot derivatives, inducers of CYP3A4 or 2C19 (e.g., anticonvulsants, rifampicin, St John's wort).

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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