Pharmacristine

by Pharmedic

Active ingredient: Vincristine

Packs

About Vincristine

Cytostatic

Uses

Leukaemia and other malignant conditions.

How to take it

Adults & Elderly: Antineoplastic (typical dosages): IV: 0.4-1.4 mg/m², may repeat every wk or 0.4-0.5 mg/day continuous infusion for 4 days every 4 wk or 0.25-0.5 mg/m²/d continuous infusion for 5 days every 4 wk. Also refer individual protocols for dosages. Neuroblastoma: IV continuous infusion with doxorubicin: 1 mg/m²/day for 72 hr. Children: <10 kg or BSA<1 m²: Initial therapy: 0.05 mg/kg once wkly then titrate dose; max single dose: 2 mg. Children: >10 kg or BSA>1 m²: 1-2 mg/m², may repeat once wkly for 3-6 wk; max single dose: 2 mg. IV: Usually administered as slow (1-2 min) push or short (10-15 min) infusion; 24 hours continuous infusions are occasionally used. Reconstitution:…

Side effects

Alopecia, hypotension, hypertension, seizures, headache, rash, hyperuricaemia, constipation, GI upsets.

Pregnancy and breastfeeding

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Patients with demyelinating form of Charcot- Marie- tooth syndrome. Precautions: Impaired hepatic function, elderly, pre-existing neuromuscular disease.

Advice

This medication is administered by infusion. Report immediately redness/swelling/pain/burning at infusion site. Contact prescriber if there is fever, chills, sore throat, burning on urination, fatigue, muscle pain or weakness, jaw pain or weakness, numbness or tingling in toes or fingers, unusual bruising or bleeding, dark coloured stool, blood in stool, urine or mouth, difficulty in breathing, skin rash, skin itching, unrelieved mouth sores. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Take small, frequent meals to maintain good nutritional status. Avoid highly crowded places to prevent infection. Do not get vaccinated…

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Interactions with Vincristine

Digoxin, CYP3A4 enzyme inhibitors, mitomycin C.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.