M-dopa

by Linear

Active ingredient: Methyldopa

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About Methyldopa

Antihypertensive

Uses

All grades of hypertension.

How to take it

Tab: Adults: Initially 250 mg two or three times daily, adjust at two day intervals; max 3 gm daily. Elderly: Initially 125 mg twice a day, dose should be increased gradually. Max: 2 gm/day. Children: Not recommended.

Side effects

Sedation, headache, asthaenia, depression, bradycardia, nasal congestion, dry mouth, Gl upset, positive Coomb's test, jaundice haemolytic anaemia.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: Active liver disease. Depression. Catecholamine-secreting tumours (e.g., phaeochromocytoma, paraganglioma). Precautions: Haemolytic anaemia. History of liver disorder. Monitor liver function and WBC before therapy and for first 6-12 weeks or in case of fever. Renal impairment. Anaesthesia. Severe bilateral cerebrovascular disease. Porphyria.

Advice

Take with or without meals. Contact prescriber if there is disturbed mental status (increased nervousness, depression, anxiety, nightmares); rapid weight gain; unusual or constant swelling of ankles, feet or extremities; rapid heartbeat; palpitations; fever; bruising; rash; prolonged dizziness; constant weakness; yellow eyes or skin; unusual bleeding or fatigue. Hypertension can return within 48 hours after stopping drug. Do not stop taking medication abruptly. Gradually slow down the dosage. To minimize daytime drowsiness, take medicine at bed time. Change position slowly. Weigh yourself in same dress at the same time of day once weekly, report to prescriber if weight gain is more than 5…

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Interactions with Methyldopa

TCADs, MAOIs, other antihypertensives, rauwolfia alkaloids, hydralazine, phenothiazines, lithium, iron, sympathomimetics.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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