Lanzapin-F

by Adamjee

Active ingredients: Fluoxetine HCl, Olanzapine

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About Fluoxetine

Antidepressant

Uses

Depression, especially where sedation is not required. Bulimia nervosa. Obsessive compulsive disorder.

How to take it

Anxiety/hypnotics: Panic disorder: Adults: Initial: 10 mg/day. May increase to 20 mg/day after 1 wk. May increase further after several wk if needed. Max: 60 mg/day. Depression: Adults: Daily Dosing: Initial: 20 mg every morning. Titrate: Increase dose if no improvement after several wk. Doses >20 mg/day, give every morning or twice daily (morning and noon). Max: 80 mg/day. Children: >8 yr: Higher Weight Paeds: Initial: 10 or 20 mg/day. After 1 wk at 10 mg/day, may increase to 20 mg/day. Lower Weight Paeds: Initial: 10 mg/day. Titrate: May increase to 20 mg/day after several wk if clinical improvement not observed. Premenstrual dysphoric disorder: Adults: Continuous: Initial: 20 mg daily.…

Side effects

Nausea, headache, anxiety, vomiting, insomnia, dizziness and asthaenia, rash. Convulsions, hypomania and mania, anorexia, sleep disorders, restlessness, decreased libido, disturbance in attention, dysgeusia, somnolence, tremor, blurred vision, palpitations, QT prolongation, flushing, yawning, GI upset, dry mouth, rash and allergic reactions, increased sweating, arthralgia, urinary frequency, gynaecological bleeding, sexual dysfunction, fatigue, chills, wt loss, serotonin syndrome, bleeding disorders, seizures, erythema multiforme. Children and adolescents: Suicide-related behaviour, epistaxis, growth retardation, decreased alkaline phosphatase.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Severe renal failure. Unstable epilepsy. Within 2 weeks of stopping MAOIs or 1 day of stopping moclobemide. Precautions: Hepatic impairment, diabetes, cardiac disease, stable epilepsy, psychosis, ECT, mania, risk of bleeding, raised IOP, narrow-angle glaucoma, or history of glaucoma. Monitor for suicidal ideation. Risk factors for QT prolongation or torsade de pointes. Advise patients to report cardiovascular symptoms. Monitor growth and pubertal development in children during and after treatment. Dose increases may be detrimental in patients who develop akathisia. Poor CYP2C19…

Advice

Take with or without meals. Take single daily dose in morning. Do not stop taking medication abruptly, gradually lower the dose and then stop. Contact prescriber if there is headache, excitation, anxiety, increased sleepiness, restlessness, nervousness, lack of sleep, muscle cramps, tremors, change in gait, skin rash, skin irritation, difficulty in breathing or if there is worsening of condition. Avoid alcohol and caffeine during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Maintain regular dietary intake to avoid excessive weight loss. Change position slowly from sitting or lying to standing. If you have…

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Interactions with Fluoxetine

MAOIs, lithium, tryptophan, St. John's Wort, 5HT1 agonists, triptans, other serotonergic drugs, linezolid, drugs that prolong QT interval, tramadol, anticoagulants, metabolized by CYP2D6 (e.g., flecainide, carbamazepine, tamoxifen), metoprolol, TCADs, haloperidol, phenytoin, clozapine, tramadol, diuretics, drugs affecting platelet function, ECT.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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