La-pen

by PDH Pharma

Active ingredient: Benzathine penicillin

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About Benzathine Penicillin G

Plain, Medium & Narrow-spectrum Penicillin

Uses

Mild to severe streptococcal infections Group A (without Bacteraemia) of the upper respiratory tract, skin and soft tissues, scarlet fever and erysipelas. Pneumococcal infections: moderately severe pneumonia, otitis media.

How to take it

Streptococcal infections Group A: Adults: 2.4 million units. Children: 30-60 lbs, 0.9-1.2 million units; infants & children under 30 lbs, 0.6 million units. All by deep IM inj at a single session using multiple IM sites when indicated. An alternate dosage schedule may be used giving 1/2 the total dose on day 1 and 1/2 total dose on day 3. Pneumococcal infections (except pneumococcal meningitis): Adults: 1.2 million units. Children: 0.6 million units. (All by deep IM inj repeated every 2 or 3 days until the temperature is normal for 48 hr.). IM: Give undiluted injection; administer by deep IM injection in the upper outer quadrant of the buttock; do not give IV, intra-arterially or SC. IM…

Side effects

Anaphylaxis. Glossitis, stomatitis, gastritis, sore throat, dry mouth, furry tongue. Anaemias. Haemorrhagic manifestation. Interstitial nephritis (e.g. oliguria, hematuria). Nephrotoxicity.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: History of previous hypersensitivity reaction to penicillins and/or cephalosporins. Do not inject parenteral solutions into or near an artery or nerve. Precautions: Streptococcal infection: Therapy must be sufficient to eliminate the organism (a minimum of ten days). Otherwise the sequela of streptococcal disease (endocarditis, rheumatic fever) may occur. Avoid small ineffective doses of penicillin as resistant organisms are more likely to emerge.

Advice

This medication is administered by injection only. Contact prescriber if there is redness/swelling/burning/pain at infusion site or if there is difficulty in breathing or swallowing, chest tightness, hives, rash, swelling of mouth or lips, chills, fever, unhealed sores, white plaques in vagina or mouth, purulent vaginal discharge, fatigue. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. If you are taking this medication for sexually transmitted disease, your partner should also be treated.

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Interactions with Benzathine Penicillin G

Concurrent administration of bacteriostatic antibiotics (e.g. erythromycin, tetracycline) may diminish the bactericidal effects of penicillins. Probenecid prolongs penicillin blood levels. Oral contraceptives may be rendered less effective & an increased incidence of breakthrough bleeding may occur when administered with ampicillin or penicillin V.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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