Ibrance
by Pfizer
Active ingredient: Palbociclib
Packs
- Cap · 125 mg · 21's (103788)
- Cap · 100 mg · 21's (103787)
- Cap · 75 mg · 21's (103786)
- Cap · 100 mg · 7's (103787)
- Cap · 125 mg · 7's (103788)
- Cap · 75 mg · 7's (103786)
About Palbociclib
Cytostatic
Uses
Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. In combination with letrozole for the treatment of postmenopausal women with oestrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for metastatic disease.
How to take it
Cap/Tab: Adults: Starting dose: 125 mg once daily taken with food for 21 days followed by 7 days off treatment. Dose may be adjusted as required. Children: Not recommended. In combination with a strong CYP3A inhibitor: Reduce the Palbociclib dose to 75 mg once daily. If the strong inhibitor is discontinued, increase the Palbociclib dose (after 3 to 5 half-lives of the inhibitor) to the dose used prior to the initiation of the strong CYP3A inhibitor. As initial endocrine-based therapy in combination with letrozole in postmenopausal women: Starting dose: 125 mg daily with food for 21 days followed by 7 days off therapy to comprise a complete cycle of 28 days. With letrozole 2.5 mg daily…
Side effects
Neutropenia, leukopenia, infections, fatigue, nausea, anaemia, stomatitis, headache, diarrhoea, thrombocytopenia, constipation, alopecia, vomiting, rash, decreased appetite.
Pregnancy and breastfeeding
Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Precautions: Renal or hepatic disease, neutropenia. Monitor complete blood count prior to start of therapy and at the beginning of each cycle, as well as on Day 14 of the first two cycles and as clinically indicated. Infections: Monitor for signs and symptoms and withhold dosing as appropriate. Monitor patients for signs and symptoms of pulmonary embolism. Risk of fetal harm. Advise patients of potential risk to a fetus and to use effective contraception.
Full information on Palbociclib →
Interactions with Palbociclib
Strong and moderate CYP3A inducers, strong CYP3A inhibitors. Grapefruit or grapefruit juice.
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Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.