Gala

by Shrooq

Active ingredient: Galantamine HBr

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About Galantamine HBr

Other CNS Drugs

Uses

Mild to moderately severe Alzheimer's dementia.

How to take it

Adults: Initially 4 mg twice daily or 8 mg once daily in the morning, preferably with food, for 4 wk. Then 8 mg twice daily or 16 mg once daily for at least 4 wk, increasing to maintenance 12 mg twice daily or 24 mg once daily depending on benefit and tolerance. Reduce dose to 8 mg twice daily or 16 mg once daily if not showing an increased response or not tolerating 12 mg twice daily or 24 mg once daily. Assess response within 3 mth and only continue if positive evidence of benefit and tolerance. Children: Not recommended.

Side effects

GI upset, anorexia, fatigue, dizziness, headache, somnolence, weight loss, fall, confusion, injury, insomnia, rhinitis, UTI, asthenia, syncope, tremor, hypertension, depression, hallucinations, bradycardia, hyperhidrosis, muscle spasm. Steven-Johnson syndrome, acute generalised exanthematous pustulosis, 1st degree AV block.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: Severe hepatic or renal (CrCl <9 mL/min) impairments. GI or urinary outflow obstruction, bladder or GI surgery. Precautions: Diagnosis and treatment must be initiated by a specialist in Alzheimer's dementia. Moderate hepatic impairment, cardiac conduction disturbances, electrolyte disturbances, recent MI, atrial fibrillation, 2nd degree AV block, unstable angina, congestive heart failure, cerebrovascular disease, increased risk of peptic ulcer, epilepsy, asthma, COPD, pulmonary infection, GI or urinary outflow obstruction, bladder or GI surgery. Monitor body-wt. Increased risk of…

Advice

Take with meals. Do not chew or crush tablets. Contact prescriber if there is dizziness, lack of sleep, depression, constant abdominal disturbance, increased salivation, sweating or tears, increased fatigue, increased muscle/joint/body pain or spasms, change in vision, difficulty in breathing, wheezing, chest pain or palpitations. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Change position slowly from sitting or lying to standing.

Full information on Galantamine HBr →

Interactions with Galantamine HBr

Cholinomimetics, anticholinergics, CYP2D6 or 3A4 inhibitors. Digoxin, beta-blockers, calcium antagonists, amiodarone. Depolarising muscle relaxants. Drugs with potential to cause torsade de pointes.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.