G Tant

by GT

Active ingredient: Aprepitant

Packs

About Aprepitant

Antiemetic & Gastroprokinetic

Uses

As combination therapy for prevention of acute and delayed nausea and vomiting associated with cisplatin-based chemotherapy and prevention of nausea and vomiting associated with moderately emetogenic chemotherapy.

How to take it

Adults: To be used in combination with a 5HT3-antagonist and corticosteroid. 125 mg cap 1 hr prior to chemotherapy on Day 1, then 80 mg 1 cap in the morning on Day 2 and Day 3. Children: Not recommended.

Side effects

Hiccups, asthaenia, fatigue, GI upset, headache, dizziness, anorexia, increased ALT and AST levels.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Ensure effective non-hormonal contraception during and for 2 months after treatment. Precautions: Moderate or severe hepatic impairment.

Advice

Take with or without meals. Avoid grapefruit juice and St John's Wort during therapy. Patients taking warfarin should have clotting status monitored closely for 2 weeks after first aprepitant dose, especially every 7 to 10 days during each chemotherapy cycle.

Full information on Aprepitant →

Interactions with Aprepitant

Pimozide, immunosuppressants, ergot alkaloids, fentanyl, alfentanil, etoposide, vinorelbine, antifungals, macrolides, protease inhibitors, rifampicin, phenytoin, carbamazepine, phenobarbital, oral anticoagulants, tolbutamide; any other substrate, inhibitor or inducer of CYP3A4 or substrate of CYP2C9. Irinotecan, hormonal contraceptives, St John's wort, corticosteroids, benzodiazepines.

Tell your pharmacist or doctor about every medicine you take, including herbal products.

Need G Tant? Ask us to source G Tant and our pharmacist will call you back.

Other brands with the same ingredients

More from GT

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.