Ziprasidone
Tranquilizer, Sedative/Hypnotic · Benzyl iso thiazolyl piperazine
Indications
Management of schizophrenia & other psychotic disorders & for maintenance of clinical improvement.
Dosage
Adults: ORAL: Schizophrenia: Initial: 20 mg twice daily with food. Max: 80 mg twice daily. Bipolar Disorder: Acute Manic & Mixed Episodes: Initial: 40 mg twice daily with food. Titrate: Increase to 60-80 mg twice daily on 2nd day of treatment. Maint: 40-80 mg twice daily with food. Children: Not recommended. Adults: INJECTION: Psychosis: IM: 10 mg every 2 hr or 20 mg every 4 hr, max 40 mg per day. Oral therapy should replace IM administration as soon as possible. Schizophrenia: IM: Adults: Initial: 10 to 20 mg. 10 mg dose may be given every 2 hr up to max dose; 20 mg dose may be given every 4 hr up to max dose. Max: 40 mg daily. Children: Not recommended.
Administration
Administered by IM. Reconstitute each vial with 1.2 mL of SWFI, shake vigorously, will form a pale, pink solution containing 20 mg/mL ziprasidone. Stability: Reconstituted injection may be stored at room temperature up to 24 hours, or up to 7 days if refrigerated, protect from light.
Adverse Effects
Asthaenia, headache, GI disturbances, somnolence, agitation, akathisia, dizziness, dystonia, extra-pyramidal syndrome, hypotonia, tremor, abnormal vision.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: QT-interval prolongation, recent MI, uncompensated heart failure, cardiac arrhythmias requiring treatment with Class IA & III antiarrhythmic drugs, drugs that prolong QT interval. Precautions: QT-interval prolongation, neuroleptic malignant syndrome, tardive dyskinesia, hyperglycaemia, seizures, CNS drugs/alcohol.
Interactions
Class IA & III antiarrhythmics, drugs that prolong QT interval, CNS drugs/alcohol.
Advice to Patient
Take with meals. Contact prescriber immediately if there is difficulty in breathing, chest pain, palpitations, change in vision, trembling, change in gait, increased sleepiness, seizures, severe anxiety, unusual muscle or skeletal movements, nightmares, hallucinations, confusion, suicidal thoughts, change in menstrual pattern, sexual dysfunction, change in urinary pattern, skin rash. Do not share this medication with anyone else. Empty bladder before taking medication. Avoid alcohol, caffeine, grapefruit or grapefruit juice during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Change position slowly from sitting or lying to standing. On start of therapy or change of dosage, patient should be watched carefully for suicidal tendency by caregiver or family.
Pharmacokinetics
Absorption: Well absorbed; administration with 500 calorie meals increases serum levels approx. 80%. Metabolism: Extensively hepatic. Bioavailability: Oral (with food): 60%; IM: 100%. Half-life elimination: Oral: Mean terminal half-life: Children: Mean: 3.3 to 4.1 hours. Adults: 7 hours. IM: Mean half-life: 2 to 5 hours. Time to peak: Oral: Children: Mean: 5 to 5.5 hours. Adults: 6 to 8 hours. IM: =60 minutes. Excretion: Feces, urine.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.