Vericiguat

Cardiac Therapy · SGC stimulator

Indications

To reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction <45%.

Dosage

Adults and Elderly: Initially 2.5 mg orally once daily with meals. Double the dose approximately every 2 wks to reach the target maintenance dose of 10 mg once daily, as tolerated by the patient. Children: Not recommended.

Adverse Effects

Hypotension, anaemia, dizziness, headache, GI upset.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Systolic blood pressure <100 mmHg or symptomatic hypotension. eGFR <15ml/min/1.73m2 at initiation, dialysis. Severe hepatic impairment. Precautions: Risk factors for hypotension.

Interactions

Other soluble guanylate cyclase stimulators, PDE5 inhibitors, antihypertensives, nitrates.

Advice to Patient

Take with meals. For patients unable to swallow, tablet may be crushed and mixed with water immediately before administration. Females of reproductive potential must use effective contraception during treatment and for 1 month after stopping treatment.

Pharmacokinetics

Metabolism: Via glucuronidation. Bioavailability: 93% when taken with meals. Half-life elimination: 30 hrs. Time to peak: 4 hrs (with meals). 1 hr (fasting state). Excretion: Urine (approx. 53%). Faeces 45% (primarily as unchanged drug).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.