Vecuronium Bromide
Muscle Relaxant · Non-depolarising muscle relaxant
Indications
As an adjunct to general anaesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery.
Dosage
Adults: By IV inj, initially 80-100 mcg/kg (max 250 mcg/kg) then 30-50 mcg/kg as required. By IV infusion, 50- 80 mcg/kg/hr. Children: Not recommended for assisted ventilation in intensive care. To avoid excessive dosage in obese children, dose should be calculated on the basis of ideal weight. Neuromuscular blockade (intermediate duration) during surgery: Neonate, by IV injection initially 80 mcg/kg, then 30-50 mcg/kg adjusted according to response; 1 mth-18 yr by IV injection initially 80-100 mcg/kg, then either by IV injection, 20-30 mcg/kg repeated as required or by IV infusion, 0.8-1.4 mcg/kg/minute, adjusted according to response. Assisted ventilation in intensive care: IV injection: Neonate, initially 80 mcg/kg, then 30-50 mcg/kg adjusted according to response. IV infusion: Neonate, IV injection 80 mcg/kg, then by IV infusion, 0.8-1.4 mcg/kg/minute, adjusted according to…
Administration
IV: Conc of 1 mg/mL may be administered by rapid IV injection. Reconstitution: May further dilute reconstituted vial to 0.1-0.2 mg/mL in a compatible solution for IV infusion. Conc. of 1 mg/mL may be used for IV infusion in fluid-restricted patients. Compatibility: Incompatible with alkaline solution and medications. Y-site administration: Drug to Drug IV Compatibility: Amiodarone, cephazolin, cimetidine, diltiazem, dobutamine, dopamine, epinephrine, esmolol, fentanyl, fluconazole, gentamicin, heparin, hydrocortisone, hydromorphone, labetalol, linezolid, lorazepam, midazolam, milrinone, morphine, nitroglycerin, nitroprusside, norepinephrine, propofol, ranitidine, vancomycin. Drug to Drug IV Incompatibility: Furosemide, thiopental. In syringe: Incompatible with thiopental. Stability: Store intact vial of powder for injection at room temperature 15°C-30°C. Vials reconstituted solutions…
Adverse Effects
Skeletal muscle weaknes or paralysis, apnoea, bronchospasm, hypotension, tachycardia, acute urticaria, erythema, minimal induration, redness, itching, CV effects, myopathy. Potentially Fatal: Anaphylaxis.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Precautions: Neuromuscular disease, severe obesity, after poliomyelitis. Electrolyte imbalances, dehydration, acidosis, renal insufficiency and liver disorders, Myasthaenia gravis, Eaton-Lambert syndrome.
Interactions
Anaesthesia, non-depolarising muscle relaxants, suxamethonium, aminoglycosides, polypeptide antibiotic, diuretics, beta-adrenergic blockers, thiazides, MAOIs, quinidine, protamine, imidazole, metronidazole, alpha-adrenergic blockers, neostigmine, corticosteroids, noradrenaline, theophylline, azathioprine, potassium chloride, sodium chloride, calcium chloride, edrophonium.
Advice to Patient
Before administration, patient is usually unconscious. Continuous monitoring is required during and after administration. After muscle tone becomes normal, do not change position and rise up without help. Contact prescriber if there is difficulty in breathing, muscle tremors, fast heartbeat, skin rash, hives.
Pharmacokinetics
Onset: 1 min. Absorption: Rapid. Metabolism: Hepatic. Half-life elimination: Biphasic. Initial: 3.3-9 mins. Terminal: 65-75 mins. Time to peak, plasma: 3-5 mins. Excretion: Faeces (mainly). Urine. (small amounts).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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