Valsartan, Amlodipine and Hydrochlorothiazide

Angiotensin-II Antagonist · Angiotensin II antagonist/Calcium antagonist/Thiazide diuretic

Indications

Hypertension.

Dosage

Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.

Adverse Effects

Nasopharyngitis, flu. Headache. Oedema (pitting, facial, peripheral), fatigue, flushing, asthaenia, hot flush.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Biliary cirrhosis or cholestasis. Precautions: Patients with activated renin-angiotensin system who are receiving angiotensin receptor blockers; hepatic impairment or biliary obstructive disorders; CrCl <10 mL/min; aortic or mitral stenosis or obstructive hypertrophic cardiomyopathy. Hyperkalaemia.

Interactions

K supplements, K-sparing diuretics, K-containing salt substitutes or other drugs that may increase K levels (heparin, etc.).

Advice to Patient

Take with or without meals.

Pharmacokinetics

VALSARTAN: Onset of action: Approx. 2 hrs. Duration: 24 hrs. Metabolism: To inactive metabolite. Bioavailability: Tab: 25%. Susp: Approx. 40%. Half-life elimination: Children 1-5 yrs: Approx. 4 hrs. 6-16 yrs: Approx. 5 hrs. Adults: Approx. 6 hrs. Time to peak, serum: Children 1-16 yrs: Oral susp: 2 hrs. Adults: 2-4 hrs. Excretion: Faeces (83%). Urine (13%). AMLODIPINE: Onset of action: Antihypertensive effect: Significant reductions in blood pressure at 24-48 hrs after first dose. Duration: Antihypertensive effect: At least 24 hrs. Discontinuation after 6-7 wks of treatment: Duration extends to at least 72 hrs. Absorption: Well absorbed. Metabolism: Hepatic. Bioavailability: 64%-90%. Half-life elimination: Terminal (biphasic): 30-50 hrs. Time to peak, plasma: 6-12 hrs. Excretion: Urine. HYDROCHLOROTHIAZIDE: Onset of action: Diuresis: Infants: 2-6 hrs. Adults: Approx. 2 hrs. Peak…

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.