Tropisetron

Antiemetic & Gastroprokinetic · 5HT3-antagonist

Indications

Nausea and vomiting induced by chemotherapy. Treatment of post-operative vomiting, prevention of post-operative vomiting in patients undergoing intra-abdominal gynaecological surgery.

Dosage

Nausea and vomiting induced by chemotherapy: Adults: 5 mg by slow IV inj or infusion shortly before chemotherapy, followed by 1 cap each morning 1 hr before food for 5 days. Children: Over 2 yr, 0.2 mg/kg by slow IV inj or infusion shortly before chemotherapy up to a max daily dose of 5 mg. In children under 25 kg, repeat IV administration on day 2 up to day 5 depending on chemotherapy regimen. In children over 25 kg, 5 mg orally on day 2 up to day 6. Treatment of post-operative nausea and vomiting: Adults: 2 mg dose by IV inj or infusion within 2 hr of the end of anaesthesia. Prevention of post-operative nausea and vomiting: Adults: 2 mg dose by slow IV inj or infusion shortly before induction of anaesthesia.

Administration

Intermittent or via drip tubing in dextrose 5% or NaCl 0.9% or Ringer's solution. Suggested concentration for infusion is 50 mcg/ mL.

Adverse Effects

Headache, constipation, dizziness, fatigue. GI disturbance. Rarely, collapse, syncope, bradycardia, cardiovascular arrest.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Precautions: Uncontrolled hypertension, cardiac rhythm or conduction disturbances.

Interactions

Rifampicin and drugs affecting liver enzymes or prolong QT interval.

Pharmacokinetics

Absorption: Oral: Well absorbed from the GI tract. Metabolism: Hepatic. Bioavailability: Approx. 60%-80%. Half-life elimination: Extensive metabolizers: 8 hrs. Poor metabolizers: Up to 45 hrs. Time to peak, plasma: Within 3 hours. Excretion: Mainly urine. Faeces (small amount).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.