Trimethoprim and Sulphadimidine

Trimethoprim & Combinations · Folic acid inhibitor/Sulphonamide

Indications

Infections caused by gram-positive and gram-negative organisms.

Dosage

Susp: Adults: 20 mL twice daily. Children: 6 mth-5 yr, 5 mL; 5-12 yr, 10 mL. Both twice daily.

Adverse Effects

Nausea. Glossitis, rash, hyperkalaemia. Blood dyscrasias, folate deficiency.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Neonates. Severe renal or hepatic insufficiency. Precautions: Renal impairment. Severe allergy or asthma, folate or G6PD deficiency. Porphyria. Perform monthly blood count during long term therapy or in elderly or folate deficient; consider folate supplement. Discontinue if rash develops. Maintain adequate urinary output. Monitor serum potassium and sodium in those at risk of hyperkalaemla or hyponatraemia. Elderly.

Interactions

Folate inhibitors, anticoagulants, phenytoin, hypoglycaemics, cyclosporin, procainamide, amantadine, lamivudine, thiazide, pyrimethamine, digoxin.

Pharmacokinetics

TRIMETHOPRIM: Absorption: Oral: Rapidly and almost completely absorbed from the GI tract. Metabolism: Hepatic. Half-life elimination: Adults: 8-10 hrs. Less in children. Prolonged in neonates and in patients with renal impairment. Time to peak, plasma: 1-4 hrs. Excretion: Urine (40%-60%). Faeces. (small amounts). SULPHADIMIDINE: Absorption: Well absorbed from the GI tract. Half-life elimination: Fast acetylators: 1.5-4 hrs. Slow acetylators: 5.5-8.8 hrs.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.