Tinidazole

Amoebicide · 5-Nitro imidazole derivative

Indications

Prophylaxis and treatment of infection due to anaerobes.

Dosage

Adults: Anti-infective: Giardiasis: 2 gm single dose. Amoebiasis: Intestinal: 2 gm daily for 3 days. Amoebic Liver Abscess: 2 gm daily for 3-5 days. Gynaecology: Trichomoniasis: 2 gm single dose with food. Treat sexual partner with same dose. Bacterial vaginosis: 2 gm as a single dose. Children: Intestinal amoebiasis: 1 mth-12 yr, 50-60 mg/kg, max 2 gm, once daily for 3 days; 12-18 yr, 2 gm once daily for 2-3 days. Amoebic involvement of liver: 1 mth-12 yr, 50-60 mg/kg, max 2 gm, once daily for 5 days; 12-18 yr, 1.5-2 gm once daily for 3-6 days. Urogenital trichomoniasis and giardiasis: 1 mth-12 yr, single dose of 50-75 mg/kg, max 2 gm, repeated once if necessary; 12-18 yr, single dose of 2 gm, repeated once if necessary. Bacterial vaginosis: 2 gm as a single dose.

Adverse Effects

Gl distress, furred tongue, anorexia, vertigo, headache, skin reactions, unpleasant taste. Urticaria, angioedema, CNS disturbances, dark urine. Neuropathy and leucopenia on long term therapy.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Blood dyscrasias. Neurological disorders. Precautions: Haemodialysis. Discontinue if abnormal neurological signs develop.

Interactions

Alcohol, oral anticoagulants.

Advice to Patient

Take with meals or immediately after meals. If you are unable to swallow tablets, crush and mix in artificial cherry syrup and then take with food. Avoid alcohol during therapy and for 3 days after last dose. Complete full course of therapy even if you feel better. Do not skip doses.

Pharmacokinetics

Absorption: Oral: Rapidly and almost completely absorbed. Metabolism: Hepatic. Half-life elimination: 12-14 hrs. Time to peak, plasma: 2 hrs. Excretion: Urine (20%-25%). Faeces (12%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.