Terbinafine, Oral

Antifungal, Systemic · Allylamine antifungal

Indications

Fungal infections of the skin, hair and nails including dermatophytes and yeast infections of the skin.

Dosage

Adults: 250 mg once daily. The duration of treatments: Tinea pedis: 2-6 wk. Tinea corporis, cruris: 2-4 wk. Cutaneous candidiasis: 2-4 wk. Onychomycosis: 6 wk-3 mth. Children: Not recommended.

Adverse Effects

Gastrointestinal symptoms, skin reactions, taste disturbance, hepatobiliary dysfunction, haematological disorders, anorexia, headache, arthralgia, myalgia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: Hypersensitivity to terbinafine. Chronic or active liver disease, severe renal impairment (CrCl <50 mL/min). Precautions: Stable chronic liver dysfunction or impaired renal function, psoriasis, lupus erythematosus. Perform LFTs before and during therapy, discontinue if hepatotoxicity develops.

Interactions

Cyclosporin, tolbutamide, oral contraceptives, CYP inducers or inhibitors incl cimetidine, fluconazole, ketoconazole, rifampicin, amiodarone, CYP2D6 substrates incl TCADs, B-blockers, SSRIs, MAOIs, antiarrhythmics, caffeine.

Advice to Patient

Take with or without meals. Take at regular intervals, as scheduled. Contact prescriber if there is no improvement or worsening of condition. Complete full course of therapy even if you feel better. Avoid alcohol intake during therapy.

Pharmacokinetics

Absorption: Children and Adults: >70%. Metabolism: Hepatic. Bioavailability: Children: 36%-64%. Adults: 40%. Half-life elimination: Terminal half-life: 200-400 hrs. Effective half-life: Children: 27-31 hrs. Adults: Approx. 36 hrs. Time to peak, plasma: Children and Adults: Within 2 hrs. Excretion: Urine (80%). Faeces (20%).

Brands with this active ingredient

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.