Telmisartan and Hydrochlorothiazide

Angiotensin-II Antagonist · Angiotensin II antagonist/Thiazide diuretic

Indications

Hypertension not adequately controlled by telmisartan alone.

Dosage

Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.

Adverse Effects

Dizziness, headache, back pain, fatigue, stomach upset, hyperkalemia and diarrhoea, photosensitivity (discontinue), acute angle-closure glaucoma (discontinue).

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Cholestasis, biliary obstruction, severe hepatic or severe renal impairment, refractory hypokalaemia, hypercalcaemia, primary aldosteronism. Precautions: Mild to moderate hepatic impairment, progressive liver disease, renovascular hypertension. Mild to moderate renal impairment, kidney transplant, intravascular volume depletion, severe congestive heart failure, renal artery stenosis, aortic or mitral stenosis, obstructive cardiomyopathy, gout, asthma, SLE, diabetes. Monitor serum electrolyte, creatinine and uric acid levels during therapy.

Interactions

Lithium, digoxin, diuretics, corticosteroids, ACE inhibitors, K+-sparing diuretics or K+ supplements, cyclosporin, tacrolimus, hypoglycaemic agents, anionic exchange resins, NSAIDS, pressor amines, allopurinol, probenecid, sulfinpyrazone, calcium supplements, diazoxide, beta-blockers, anticholinergics, amantadine, methotrexate, cyclophosphamide, baclofen, alcohol barbiturates, antidepressants, other antihypertensives, other drugs affected by serum K+ disturbances, drugs that cause torsade de pointes, ACTH, amphotericin, laxatives, benzylpenicillin, muscle relaxants, colestyramine, colestipol, aspirin, sympathomimetics, uricosuric agents, calcium suppl, cytotoxics, CNS depressants.

Advice to Patient

Take with or without meals.

Pharmacokinetics

TELMISARTAN: Onset of action: 1-2 hrs. Duration: Up to 24 hrs. Metabolism: Hepatic. Bioavailability (dose dependent): 42%-58%. Hepatic impairment: Reaches 100%. Half-life elimination: Terminal: 24 hrs. Time to peak, plasma: 0.5-1 hr. Excretion: Faeces (97%). HYDROCHLOROTHIAZIDE: Onset of action: Diuresis: Infants: 2-6 hrs. Adults: Approx. 2 hrs. Peak effect: 4-6 hrs. Duration: Infants: 8 hrs. Adults: 6-12 hrs. Absorption: Well absorbed, absorption is decreased in patients with CHF. Metabolism: Not metabolized. Bioavailability: 65%-75%. Half-life elimination: Approx. 6-15 hrs. Time to peak: Approx. 1-5 hrs. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.